喜炎平注射液治疗小儿肺炎的系统评价

Xiyanping Injection in the Treatment of Infantile Pneumonia:A Systematic Review

目的:评价喜炎平注射液治疗小儿肺炎的疗效。方法:检索Medline(1966-1-2009-12)、EMbase(1966-1-2009-12)、Cochrane Library(2009年第4期)、中国生物医学文献光盘数据库(CBM,1978-1-2009-12)、中国期刊全文数据库(CNKI,1979-1-2009-12)、中国科技期刊数据库(1989-1-2009-12)、万方数据库(1982-1-2009-12)等数据库,收集喜炎平注射液治疗小儿肺炎的临床随机对照试验,对纳入的研究进行质量评价,采用RevMan5.0.24软件进行Meta分析。结果:共纳入23项随机对照研究,所有研究Juni评分均为C级,属于低级质量研究。Meta分析结果表明,与对照组比较,喜炎平注射液治疗小儿肺炎在提高肺炎临床总有效率方面显示出较好的疗效。结论:根据目前获得的低质量研究,喜炎平注射液治疗小儿肺炎有效。但纳入的临床试验在样本量、随机、双盲等方面尚存在缺陷,有必要设计良好的大样本随机双盲对照研究进行论证。

OBJECTIVE： To evaluate the therapeutic efficacy of Xiyanping injection in the treatment of infantile pneumonia. METHODS ： Electronic databases including Medline （1966-1 - 2009-12）, EMbase （1966-1 - 2009.12）, Cochrane Library （2009 No.4）, CBMdisc （1978-1 - 2009-12）, CNKI（1979-1 - 2009-12）, China Science and Technology Periodical Database（1989-1 - 2009-12）, Wanfang database（ 1982-1-2009-12） were searched to collect the randomized controlled clinical trials （RCTs） on Xiyanping injection in the treatment of infantile pneumonia. The quality of included trials was evaluated and Meta-analysis was performed by RevMan 5.0.24 software. RESULTS： A total of 23 RCTs scored C degree, which were lower quality. Results of the meta-analysis showed that compared with control group, Xiyanping injection appeared to be more effective in improving the total effective rate in the treatment of infantile pneumonia. CONCLUSION： Based on currently available low-quality studies, Xiyanping injection is an effective treatment for infantile pneumonia. However, some aspects （sample size, randomized, doubled-blind, etc.） of the included trials remain defect, thus well-designed large-scale and randomized double-blind controlled trials are required.