摘要
MicroRNA(miRNA)是近年发现的一类大小约21—22个核苷酸的非编码小RNA分子,它主要通过RNA诱导的沉默复合体(RNA—inducedsilencingcomplex,RISC)来调控基因的表达,参与调控机体的各种生理功能。因此,miRNA的功能失调与人类疾病的发生、发展密切相关。该文就miRNA在多种疾病的诊断和治疗方面的研究进展作一综述。
MicroRNAs (miRNAs) are non-encoded small RNAs discovered in recent years with about 22 nucleotides in length. They mediate the genes expression by RNA-induced silencing complex (RISC) and regulate various physiological processes in the body. Therefore, dysreguiated miRNA function may lead to human diseases. This review briefly introduced the progresses on microRNAs in diagnosis and treatment of various diseases.
出处
《国际医学寄生虫病杂志》
CAS
2011年第5期305-310,共6页
International JOurnal of Medical Parasitic Diseases
基金
基金项目:国家重点基础研究发展规划项目(973计划)(2010CB530004)