慢性肾功能不全患者心脏瓣膜钙化相关因素的分析

Analysis of relative factors of heart valve calcification in chronic renal dysfunction patients

目的:分析慢性肾功能不全,导致心脏瓣膜钙化的相关因素。方法:以50例慢性肾功能不全患者为研究组,50例健康体检者作为对照组,行彩色超声心动图及相关血生化指标检查,分析心脏瓣膜钙化的相关因素。结果:1.研究组患者心脏瓣膜钙化发生率明显高于对照组(P<0.01),发生钙化的年龄明显低于对照组(P<0.05);2.研究组心脏瓣膜钙化患者的年龄、钙磷乘积(Ca×P)、C-反应蛋白(CRP)明显高于对照组患者,前白蛋白、总蛋白、白蛋白明显低于对照组患者。结论:慢性肾功能不全患者,因疾病消耗、血液透析、营养不良、炎症、动脉粥样硬化以及钙磷代谢紊乱等,均使患者心脏瓣膜钙化的发生率明显增加。

Objective：To analyze relative factors contribute to heart valve calcification in chronic renal dysfunction patients.Methods：100 people were divided into experiment group（n =50） with chronic renal dysfunction and control group（n =50） with healthy volunteers.The heart valves were evaluated with echocardiography,and relative biochemical criterion was examed.Results：1.Ratio of heart valve calcification in experiment group was higher than control group（P 0.01）.Among the people with heart valve calcification,people in the experiment group are younger than those in control group（P 0.01）.2.Age,Ca ×P,CRP level in experiment group was higher,but level of prealbumin,albumin and total protein was lower than the patients in control group.Conclusion：Heart valve calcification is increased in people with chronic renal dysfunction because of hemodialysis,dystrophy,inflammation,atherosclerosis and metabolic disturbance of calcium and phosphor.