重型颅脑损伤甲状腺素水平与预后的关系

Relationships Between the Prognosis of Severe Traumatic Brain Injury and the Thyroxin Level

目的：探讨重型颅脑损伤患者甲状腺素水平变化与预后之间的关系。方法：回顾性分析我科2008-03-2009-07收治的80例重症颅脑损伤病人的临床资料,以入院初始甲状腺水平为分组依据,将入选对象分成低甲状腺素水平组（32例）及正常甲状腺素水平组（48例）,比较两组病人GOS预后评分的差异。结果：入选对象中,低甲状腺素水平组病人平均GOS评分低于正常甲状腺水平组（t=-2.115,P=0.041〈0.05）。结论：甲状腺素水平变化与重型颅脑损伤病人的预后密切相关,重型颅脑损伤合并低甲状腺素水平的患者可能具有更加不良的预后,提示重型颅脑损伤后甲状腺素水平的变化可能具有预测该类病人临床预后的潜能。

Objective：To investigate the relationships between prognosis of patients with severe traumatic brain injury and the changes of thyroxin level caused by head trauma.Methods：Oretrospectively analyze the clinical data of 80 patients with severe traumatic brain injury in our department from 2008-3-2009-7.According to the different level of thyroxin,all cases were divided into two groups,including hypo-thyroxin group（48 cases） and normal thyroxin group（48 cases）.Prognosis evaluated by GOS evaluation system was compared between these two groups.Results：By compared with the normal thyroxin group,the hypo-thyroxin group had the lower mean GOS score in all cases（t=-2.115,P=0.0410.05）.Conclusions：Thyroxin level′s change had a good relationship with prognosis of patients with severe traumatic brain injury,it seemed that patients with severe traumatic brain injury combing with low thyroxin state would suffer the poor prognosis,and which mend that the thyroxin level′ change may have the power to predict the clinical prognosis of patients with severe traumatic brain injury.