慢性乙型肝炎临床表现形式与乙肝病毒基因型的关系分析

Relationship of HBV genotypes and clinical manifestations in patients with chronic hepatitis B

目的:探讨慢性乙型肝炎基因型与慢性乙型肝炎临床表现类型的关系。方法:对35例慢性乙型肝炎轻度,32例慢乙肝中度以及30例慢乙肝重度患者的血清采用荧光定量PCR技术进行乙肝病毒基因型的检查,分析慢性乙型肝炎的三种表现与乙肝病毒基因型的关系。结果:97例慢性乙肝患者共检出B型基因为39例(40.21%),C型基因为58例(59.79%),在慢性乙型肝炎轻度、中度、重度各组间基因型B和C分布差别无统计学意义(P>0.05),B和C基因型中HBeAg和HBV-DNA载量的表达有差别(P<0.05),C基因型的HBeAg和HBV-DNA载量表达要高于B基因型。结论:本地区慢性乙型肝炎基因型以B和C感染为主,基因型与慢性乙型肝炎轻、中、重分级无关系,C型基因的HBeAg和HBV-DNA载量表达要高于B基因型。

Objective： To study the distribution of HBV genotypes in patients with HBV-related chronic liver disease and its relationship with clinical manifestations.Methods： 35 patients with HBV-related chronic mild,32 patients with HBV-related chronic moderate and 30 patients with HBV-related chronic severe hepatitis were inspected for hepatitis B virus genotypes in serum by fluorescent quantitative PCR technology.The relationship between three manifestations of chronic hepatitis B and HBV genotypes was analyzed. Results： Of the 97 patients,39（40.21%） were genotype B,58（59.79%） were genotype C,There was no significant difference for B and C genotype distribution among patients with HBV-related chronic mild,moderate and severe hepatitis（P0.05）.Serum HBeAg positive rate and HBV-DNA load in patients infected with HBV type C was significantly higer than that in patients infected with HBV type B（P0.05）.Conclusion： In this area,HBV genotypes are mainly type B and C,HBV genotypes were not related to HBV-related chronic mild,moderate and severe hepatitis.Serum HBeAg positive rate and HBV-DNA load in patients infected with HBV type C was significantly higer than that in patients infected with HBV type B.