2008年-2010年广州地区手足口病流行比较

Analysis of the hand-foot-mouth diseases in Guangzhou from 2008 to 2010

目的:了解2008年-2010年期间广州地区手足口病病例标本中CoxA16和EV71的感染情况。方法:采集临床诊断为手足口病患者的粪便、咽拭子及肛拭子标本,用Real-time PCR同时检测总肠道病毒、CoxA16和EV71。结果:2008年、2009年和2010年,总肠道病毒阳性率分别为9.28%、37.85%和61.76%,其中,CoxA16的阳性率分别为32.35%、55.00%和31.59%,EV71的阳性率分别为29.41%、13.33%和67.39%。2008年-2010年,总肠道病毒阳性率呈逐年升高趋势。结论:CoxA16和EV71为广州地区2010年手足口病的主要病原。

Objective： To understand the infection of CoxA16 and EV71 in hand,foot and mouth cases in Guangzhou from 2008 to 2010.Methods： Stool specimens,throat swab and anal swab were detected by flueorecent PCR to check pan-enterovirus,Coxsackie A16 and Enterovirus 71.Results： Form 2008 to 2010,the positive rate of pan-enterovirus were 9.28%,37.85% and 61.76%.In the pan-enterovirus positive samples,the positive rate of Coxsackie A16 are 32.35%,55.00% and 31.59%,of Enterovirus 71 were 29.41%,13.33% and 67.39%.Positive rate of pan-enterovirus increased year by year.Conclusion： Coxsackie A16 and Enterovirus 71 played an important role in the surveillance of the Hand,foot and mouth diseases.