补肾泻肝汤对大鼠前列腺组织SnoN蛋白表达的影响

Effects of Bushen Xiegan Decoction on Expression of SnoN Protein in Rat Prostate Tissues

目的:观察补肾泻肝汤对实验性大鼠前列腺增生组织SnoN蛋白表达的影响及探讨SnoN蛋白表达在前列腺增生中的作用。方法:去势加丙酸睾酮注射法复制大鼠前列腺增生模型,免疫组织化学法检测大鼠前列腺增生组织及正常前列腺组织SnoN蛋白的表达。结果:模型组大鼠前列腺组织SnoN表达水平升高,与正常前列腺组织及补肾泻肝汤组阳性表达率比较,差别有显著意义(P<0.05)。结论:SnoN参与了前列腺增生的病理过程,补肾泻肝汤对前列腺增生组织SnoN表达的改变有调节作用。

Objective： To observe the effects of Bushen Xiegan Decoction on the expression of SnoN protein in rat prostate tissues and to probe into the role of SnoN protein expression in prostatic hyperplasia.Method： Castration plus testosterone propionate injection was used to make rat model of benign prostatic hyperplasia;immunohistochemistry was taken to detect the expressions of SnoN protein of prostate hyperplasia tissue and normal prostate tissue.Results： SnoN expression levels of prostate tissue in model rats increased,there was a significant difference（P0.05） compared with the positive expression rates of the normal prostate group and Bushen Xiegan Decoction group.Conclusion： SnoN is involved in the pathological process of prostatic hyperplasia;Bushen Xiegan Decoction has the regulating role in changing SnoN expression of prostatic hyperplasia.