葡萄膜炎并发白内障术中植入肝素修饰人工晶状体

The clinical observation of heparin-surface-modified intraocular lens implanted in uveitis complicated cataract

目的评价葡萄膜炎并发白内障术中植入肝素表面修饰的PMMA人工晶状体的效果。方法98例（146眼）葡萄膜炎并发白内障行超声乳化吸出术，术中分别植入肝素修饰的PMMA人工晶状体56例（98眼）（肝素组）和未修饰PMMA人工晶状体42例（48眼）（对照组）。对两组术后视力、眼前段反应、后囊浑浊情况进行回顾性对比分析。结果矫正视力≥0．5者，肝素组86眼（87．76％），对照组27眼（56．25％），（P〈0．05）。眼前段反应：人工晶状体表面纤维素样渗出、房水细胞，均在术后1周时差异最显著（P〈0．05），虹膜后粘连在6个月后两组差异最显著（P〈0．05）。后囊浑浊发生率6个月后对照组明显高于肝素组，分别为54．17％和12。24％（P〈0．05）。结论葡萄膜炎并发白内障术中植入肝素修饰人工晶状体能显著减轻术后眼前段的炎症反应，降低后囊浑浊的发生率。

Objective To observe the clinical results of heparin-sufface-modified （HSM） PMMA intraoular lens （IOL） implanted in uveitis complicated cataract. Methods The phacoemulsifieation was performed in 146 eyes of 98 cases of uveifis complicated cataract. HSM-IOL was implanted in 56 cases （98 eyes） and PMMA-IOL in 42 cases （48 eyes）. The postoperative visual acuity, anterior chamber reaction and posterior capsular opacity （PCO） were analyzed retrospectively between the two groups. Results The best con＇ected visual acuity higher than 0.5 were in 86 eyes of HSM groups （87.76%） and in 27 eyes of PMMA groups （56.52%） , there was significant difference between the two groups （ P 〈 0.05 ）. There were significant difference （ P 〈 0.05 ） in fibrinous exudate and aqueous cells in 1 week after operation, and significant difference （ P 〈 0.05 ） in posterior synechia of iris in 6 month. There was significant difference between the two groups （P 〈 0.05） in PCO 6 months postoperatively （P 〈 0.05）. Conclusion HSM-IOL implantation can reduce the postoperative reaction in anterior segment of eyeball,and decrease the occurrance of PCO.