尿液标本中大肠埃希菌的临床分布及耐药性分析

Analysis of drug resistance and distribution in Escherichia coli from urine

目的了解医院尿液标本中大肠埃希菌(ECO)的临床分布及耐药性,为临床合理使用敏感抗菌药物提供依据。方法回顾性分析2010年4月～2011年2月间尿液标本中分离的161株大肠埃希菌的临床分布及耐药性。结果 161株大肠埃希菌主要来自泌尿内科(62.7%)、重症监护病房(13%)及内科病房(10%)。药敏结果显示对亚胺培南、美罗培南、厄他培南、哌拉西林/他唑巴坦、头孢西丁、头孢吡肟、头孢他啶、氨曲南、阿莫西林/棒酸、头孢噻肟、妥布霉素、庆大霉素、左氧氟沙星、环丙沙星、复方新诺明、头孢唑啉、呋喃妥因和氨苄西林的耐药率分别为0.00%0、.00%0、.00%5、.6%1、6.8%、23%、26.7%、33.5%、43.5%、48.4%、50.9%、52.8%、60.9%、62.1%、73.9%、80.7%、90.1%和92.5%。结论大肠埃希菌为泌尿道感染的常见病原菌,有效地控制由其造成的感染临床上应根据耐药特点合理选用抗生素。

Objective： To investigate drug resistance and clinical distribution of E.coli isolated from urine in hospital,and to provide the guidance for the rational clinical application of antibiotics.Methods：161 strains of E.coli were isolated from urine from June 2010-February 2011,whose drug resistance rates and clinical distribution were analyzed retrospectively.Results： 161 strains of E.coli were collected mainly from the Department of Urology（62.7%）,Intensive Care Unit（13%） and Medical Wards（10%）.Resistance rates to imipenem,meropenem,ertapenem,piperacillin/tazobactam,cefoxitin,cefepime,ceftazidime,aztreonam,amoxicillin/clavulanic,cefotaxime,tobramycin,cidomycin,levofloxacin,ciprofloxacin,SMZ-TMP,cefazolin,furadantin and ampicillin were 0.00%,0.00%,0.00%,5.6%,16.8%,23%,26.7%,33.5%,43.5%,48.4%,50.9%,52.8%,60.9%,62.1%,73.9%,80.7%,90.1% and 92.5%.Conclusion： E.coli is common pathogen which can cause urinary tract infection and the antibiotics should be chosen according to drug sensitivity test in the clinical practice.