和胃消痞合剂对慢性胃炎大鼠血液SOD与MDA含量影响

The Effect Hewei Xiaopi Mixture(HXM)on Serum Level of SOD and MDA and Gastric Juice pH Value

目的:观察和胃消痞合剂对慢性胃炎大鼠胃炎pH值以及血液超氧岐化酶(SOD)、丙二醛(MDA)含量的影响。方法:SD大鼠74只,12只为正常对照组(A组),其余参与综合法造模,处死2只大鼠确认造模成功,然后参与造模的大鼠随机分成5组,分别为空白对照组(B组12只)、阳性对照组(C组12只)、和胃消痞合剂低剂量组(D组12只)、和胃消痞合剂(E组12只)、和胃消痞合剂高剂量组(F组12只)。造模完成后,B组给予蒸馏水灌胃,C组给予三九胃泰冲剂灌胃,D、E、F组分别给予和胃消痞合剂低、中、高剂量药液灌胃,1月后处死动物。然后测定大鼠血液的SOD和MDA值和胃液的pH值。结果:A、B、C、D、E、F组的SOD值分别为173 310U/L、158 670U/L、173 050U/L、174 190U/L、172 390U/L、170 550U/L,与B组比较,A、C、D、E、F组SOD活力升高非常明显(P<0.01);A、B、C、D、E、F组的MDA值分别为8.03nmol/mL、9.79nmol/mL、7.93nmol/mL、8.32nmol/mL、7.50nmol/mL,与B组相比,A、C、E、F组MDA明显降低(P<0.05);D、E、F组间的pH值、SOD值、MDA值没有明显差别。结论:和胃消痞合剂对慢性胃炎大鼠具有一定治疗作用,提高大鼠血液SOD的活力,减少MDA含量是其机制之一。

Objective：To observe the effect Hewei Xiaopi Mixture（HXM）on serum level of SOD and MDA.Methods：12 of 74 SD were was randomLy secleted as normal control group（A）,2 rats were scrificed the rest of 62 rats were made by model of CG by methods of synthetical method.After model was the made scucsessfully,the rats except group A were randomLy the model group（B,10 rats）,Sanjiuweitai group（C,12 rats）,Low dose HXM group（D,12 rats）,middle dose group（E,12 rats） and high dose HXM group（F,12 rats）.Then,the rats of group B,C,D,E,F were given by distilled water,Sanjiuweitai,Low dose HXM,middle dose HXM and high dose HXM for 1 month,respectively.Then all the rats were scarified,the SOD、MDA and pH were measured.Results：The serun of SOD in A、B、C、D、E、F group were 173 310U/L、158 670U/L、173 050U/L、174 190U/L、172 390U/L、170 550U/L and MDA in A、B、C、D、E、F were,8.03nmol/mL、9.79nmol/mL、7.93nmol/mL、8.32nmol/mL、7.50nmol/mL Compared to groups B,the serum of SOD was significantly higher（P0.01）,the serum of MDA in group E,F was significantly higher than group B（P0.05）,except group D.Conclusion：Hewei Xiaopi Mixture could treat rats model of Chronic Gastritis by raising the serum of SOD,reducing MDA.Hewei Xiaopi Mixture benefits did not rely on given dose directly.