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紫草素β-环糊精包合物的制备工艺和体外溶出探讨 被引量:1

Preparation and dissolution determination of inclusion compound capsule of shikonin with β-cyclodextrin
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摘要 目的:研究紫草素-β环糊精包合物的制备工艺及其胶囊体外溶出度的测定。方法:以正交实验法优选紫草素-β环糊精包合物最佳制备条件,采用水饱和溶液法制备环糊精包合物,分别将紫草素-β环糊精包合物与紫草素和β环糊精物理混合物制成胶囊,考察其体外溶解度。结果:紫草素与β环糊精的最佳包合条件为紫草素与β环糊精的比例为1:2,包合时间为1.5h,包合温度为60℃,紫草素-β环糊精包合物胶囊的体外累积溶出度大于紫草素和β环糊精物理混合物胶囊。结论:紫草素-β环糊精包合物制备工艺简单易行,包合物胶囊的水溶性好,体外溶出快。 To study the preparation process of β-CD inclusion compound of shikonin and the dissolution rate of the shikonin -β-CD inclusion compound capsules. METHODS The optimized conditions of preparation were determined by orthogonal experiment design. The shikonin -β-CD was prepared by saturated water solution method, and its the dissolution rate of Shikonin was determined by β-cyclodextrin inclusion compound capsules and the physical mixture capsules. RESULTS The optimized preparation conditions of Shikonin -β-cyclodextrin are those that the ratio of shikonin and β-CD was 1 : 2, the inclusion temperature was 60 ℃ and the stirring time was 1.5 h. The accumulated dissolution of shikonin-β-CD capsule was faster than that of the physical mixture capsule. CONCLUSION The preparation process of shikonin -β-CD inclusion compound was available. The dissolution of Shikonin from the inclusion compound is significantly increased.
出处 《中国医院药学杂志》 CAS CSCD 北大核心 2011年第19期1585-1588,共4页 Chinese Journal of Hospital Pharmacy
关键词 紫草素 Β-环糊精 包合物 制备工艺 shikonin β-CD inclusion compound capsule dissolution
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