彩虹明樱蛤多糖对小鼠的免疫调节作用

Studies on immunomodulation of polysaccharide from Moerella iridescens

目的研究彩虹明樱蛤多糖对正常小鼠免疫功能的影响。方法通过小鼠免疫器官重量测定、碳粒廓清试验、血清溶血素测定、迟发型超敏反应(DTH)和NK细胞活性测定研究彩虹明樱蛤多糖对小鼠免疫功能的影响。结果彩虹明樱蛤多糖能促进小鼠脾脏发育、增强单核-巨噬细胞功能、体液免疫功能和细胞免疫功能,与对照组比较有显著差异(P<0.05或0.01)。结论彩虹明樱蛤多糖对小鼠的免疫功能具有一定的调节作用,是一种良好的免疫调节剂。

Purpose To study the effects of polysaccharide from Moerella iridescens（MIP）on immunologic function in normal mice.Methods To study the influence of MIP on immune function in mice,the weight of immune organs,carbongranular clearance ability,hemolysin production level,DTH and activity of NK cells were determined.Results Compared with control group,MIP can significantly promote development of spleen and enhance the function of monocaryon-macrophage,humoral immune and cellular immune.Conclusion The results indicated that MIP could improve the immunological function of mice.It could be a good immunomodulater.