儿童过敏性紫癜患者食物特异性IgG抗体检测分析

Serum Food-specific IgG Detection in Children with Henoch-Schonlein Purpura

目的探讨食物特异性IgG抗体与儿童过敏性紫癜的相关性。方法采用ELISA方法检测209例儿童过敏性紫癜患者血清中13种食物特异性IgG抗体。结果 209例过敏性紫癜患儿中有139例检测到1-13种食物特异性IgG阳性升高,总阳性率为66.5%(139/209);特异性IgG阳性率较高(10%以上)的主要致敏食物有2种,分别为鸡蛋(39.2%)和牛奶(38.8%);食物特异性IgG浓度分级结果表明,鸡蛋和牛奶均可引起不同程度的食物不耐受,而其余多数食物则以引起轻度不耐受(即IgG浓度为+1级)为主。统计学分析表明:不同性别患儿食物特异性IgG阳性率无显著性差异(P>0.05);7岁以下年龄组患儿食物特异性IgG总阳性率(77.9%)显著高于7-14岁年龄组患儿阳性率(59.8%,P<0.05);汉族和少数民族两组患儿食物特异性IgG总阳性率无显著性差异(P>0.05),但单种食物IgG阳性率比较发现,汉族患儿鸡蛋特异性IgG阳性率显著高于少数民族患儿(P<0.05),少数民族患儿鳕鱼特异性IgG阳性率显著高于汉族(P<0.05)。结论食物特异性IgG抗体与过敏性紫癜具有密切相关性,食物特异性IgG抗体检测对过敏性紫癜病因诊断将具有重要意义。

Objective To explore the clinical significance of food-specific IgG antibodies in serum of children with Henoch-Schonlein Purpura and provide guiding instructions for diagnosis,treatments and prevention.Methods A total of 209 children with Henoch-Schonlein Purpura were enrolled in this study.Thirteen food-specific IgG antibodies in serum of these patients were detected by ELISA assay.Results Food-specific IgG antibodies were positive in the serum of 139 cases and the total positive rate was 66.5%.The positive rates of egg and milk were the highest among all the food.There was not significantly difference between the positive rate of boys and girls（P〉0.05）.The total positive rate of the group under 7 years old was significantly higher than that in 7-14 years group.There was not significantly difference between the total positive rate of Han and minority group（P〉0.05）.However,egg-specific IgG positive rate in Han group was significantly higher than that in minority group,and codfish-specific IgG positive rate in minority group was significantly higher than that in Han group.Conclusion There was a close relationship between food-specific IgG and Henoch-Schonlein Purpura.Detection of food-specific IgG antibody in serum of patients was of importance for diagnosis,treatment and prevention in Henoch-Schonlein Purpura.