KAI1在宫颈鳞癌中的表达及临床意义

Expression and clinical significance of KAI1 in Squamous Cell Carcinoma of the Cervix

目的探讨研究KAI1在正常宫颈、宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)及宫颈鳞癌中的表达及其与宫颈鳞癌临床病理特征之间的关系,探讨其在宫颈鳞癌发生、发展和转移等方面的作用和意义。方法随机选取大庆龙南医院2009年1月-2010年10月间妇科门诊及住院手术切除的组织标本:10例正常宫颈组织、40例宫颈上皮内瘤变组织、36例宫颈鳞癌组织,应用免疫组织化学法对组织进行染色,以检测KAI1的表达情况。结果 KAI1主要在细胞膜和(或)细胞浆内表达,其在正常宫颈组织、CINⅠ、Ⅱ、Ⅲ、宫颈鳞癌组织中阳性表达呈递减趋势,依次为100%、87.5%、73.3%、63.1%、19.4%。KAI1在宫颈鳞癌表达与细胞分化程度及淋巴结转移相关,与组织浸润深度、临床分期、年龄、癌灶大小无关。提示KAI1可以抑制宫颈鳞癌的浸润和转移。结论 KAI1的高表达抑制宫颈鳞癌的发生发展,低表达可能预示着该肿瘤更具有侵袭性,预后差。

Objective to study the expression of KAI1 in normal cervical tissue,neoplasm of cervical intraepithelial and cervical squamous cell carcinoma and its relationship to clinical and pathological features of cervical squamous cell carcinoma.Methods randomly selecting surgical and outpatient resection specimens in the Longnan Hopsital of Daqing between January 2009-October 2010,including 10 cases of normal cervical tissue,40 cases of neoplasm of cervical intraepithelial and 36 cases of cervical squamous cell carcinoma,using immunohistochemical method to stain tissues to detect the expression of KAI1.Results KAI1 was mainly expressed in the membrane or cytoplasm carcinoma tissues.In normal cervical epithelial tissue,CINⅠ-Ⅲ and cervical squamous cell carcinoma the positive rates of KAI1 were100%,87.5%,73.3%,63.1%,19.4%.Expression of KAI1 was related to lymph node metastasis and grade of differentiation.there was not was related to tissue infiltration,clinical stage,age,tumor size.Conclusion The high expression of KAI1 inhibited the development of cervical squamous cell carcinoma.The low expression of KAI1 may indicate more aggressive and poor prognosis.