老年高血压伴肥胖患者血清MMP-9、MCP-1水平的变化及其临床意义的研究

Study on the changes and clinical significance of serum MMP-9,MCP-1 level in elderly patients with hypertension and obesity

目的探讨老年高血压伴肥胖患者血清基质金属蛋白酶-9(MMP-9)、单核细胞趋化因子-1(MCP-1)水平的变化及其临床意义。方法将符合纳入、排除标准的高血压患者分为高血压肥胖组和单纯高血压组,正常血压者分为单纯肥胖组和正常对照组。高血压的诊断依据2005年中国高血压防治指南诊断标准,肥胖诊断依据按BMI≥25 kg/m2(亚太地区标准)。对所有受试者进行一般检查及血糖、血脂等生化检查,Elisa法测定血清MCP-1和MMP-9水平。结果①单纯肥胖组、单纯高血压组、高血压肥胖组BMI、TG、LDL-C均较对照组升高,差异有统计学意义(P<0.05);单纯肥胖组、单纯高血压组、高血压肥胖组HDL-C均较对照组降低,差异有统计学意义(P<0.05);单纯高血压组、高血压肥胖组FPG、SBP、DBP均较对照组增高,差异有统计学意义;高血压肥胖组和单纯高血压组BMI、SBP、DBP较单纯肥胖组增高,差异有统计学意义(P<0.05);高血压肥胖组BMI、FPG、TG、TC较单纯高血压组增高,差异有统计学意义(P<0.05)。②MMP-9和MCP-1水平在对照组、单纯肥胖组、单纯高血压组和高血压肥胖组中逐渐增高,且单纯肥胖组、单纯高血压组、高血压肥胖组和对照组比较,单纯高血压组、高血压肥胖组和单纯肥胖组比较,高血压肥胖组和单纯高血压组比较,差异均有统计学意义(P<0.05)。结论血清MMP-9、MCP-1在肥胖及动脉粥样硬化进程中具有重要意义,可能加速高血压肥胖患者动脉粥样硬化进程。

Objective To investigate the changes and clinical significance of serum MMP-9,MCP-1 in elderly patients with hypertension and obesity.Methods According to bringing and removing standard option,subjects were classified as control group、simple obesity group、simple hypertension group and obesity-associated hypertension group.Diagnosis of hypertension under the guidance of China hypertension diagnostic criteria in 2005,diagnosis of obesity by body mass index according to BMI ≥25 kg/m2（Asia-Pacific standards）.A general examination and conventional blood glucose,blood lipids and other biochemical tests were detected in all subjects,serum concentrations of MMP-9 and MCP-1 levels was measured by the Elisa method.Results （1） BMI,TG,LDL-C in control group,simple obesity group,simple hypertension group and obesity-associated hypertension group,were increased gradually,and compare each of them there is a statistical significance（P〈0.05）;HDL-C in control group,simple obesity group,simple hypertension group and obesity-associated hypertension group,were decreased gradually,and compare each of them there is a statistical significance（P〈0.05）;FPG,SBP,DBP in simple hypertension group and obesity-associated hypertension group higher than control group,and compare each of them there is a statistical significance（P〈0.05）;BMI,SBP,DBP in simple hypertension group and obesity-associated hypertension group higher than simple obesity group,and compare each of them there is a statistical significance（P〈0.05）;BMI,FPG,TG,TC in obesity-associated hypertension group higher than simple hypertension group,and compare them there is a statistical significance（P〈0.05）;（2） serum MMP-9 and MCP-1 concentrations in control group,simple obesity group,simple hypertension group and obesity-associated hypertension group,were increased gradually,and compare each of them there is a statistical significance（P〈0.05）.Conclusion MMP-9 and MCP-1 play very important role in the process of obesity and astherosclerosis and also can accelerate astherosclerosis.