期刊文献+

胰岛素抵抗性糖尿病发病机制的分析 被引量:12

下载PDF
导出
摘要 胰岛素抵抗是指胰岛素受体或受体后缺陷导致胰岛素在细胞中的信号障碍,使靶细胞对胰岛素的反应性下降或抵抗。这种胰岛素数量不少但质量差,或胰岛素抗体及升糖激素等物质产生过多,或者靶器官对胰岛素的反应性下降,引起胰岛素分泌不足,最终导致糖耐量异常或出现糖尿病。糖尿病人多同时伴发高血脂、高血压及肥胖等代谢综合征,
出处 《中国实验诊断学》 北大核心 2011年第9期1610-1610,F0003,共2页 Chinese Journal of Laboratory Diagnosis
  • 相关文献

参考文献20

二级参考文献121

  • 1屈纪富,程天民,郝利.参与皮肤伤口愈合的细胞及其作用的研究进展[J].中国组织工程研究与临床康复,2001,10(24):74-75. 被引量:56
  • 2Isomaa B, Almgren P, Tuomi T, Forsen B, Lahti K, Nissen M, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care, 2001, 24 (4): 683-689
  • 3Jaber LA, Brown MB, Hammad A, Zhu Q, Herman WH. The prevalence of the metabolic syndrome among Arab Americans. Diabetes Care, 2004, 27 (1): 234-238
  • 4SALTIEL A R,KAHN C R.Insulin signalling and the regulation of glucose and lipid metabolism[J].Nature,2001,414:799-806.
  • 5FREIDENBERG G R,REICHART D,OLEFSKY J M,et al.Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus.Effect of weight loss[J].J Clin Invest,1988,82:1398-1406.
  • 6PETERSEN K F,SHULMAN G I.Etiology of insulin resistance[J].Am J Med,2006,119 (Supp1.1):S10-S16.
  • 7SCHENK S,SABERI M,OLEFSKY J M.Insulin sensitivity:modulation by nutrients and inflammation[J].J Clin Invest,2008,118:2992-3002.
  • 8HOTAMISLIGEL G S,SHARGILL N S,SPREGELMAN B M.Adipose expression of tumor necrosis factor-alpha:direct role in obesity-linked insulin resistance[J].Science,1993,259:87-91.
  • 9HOTAMISLIGIL G S,PERALDI P,BUDAVARI A,et al.IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance[J].Science,1996,271:665-668.
  • 10STEPHENS J M,LEE J,PILCH P F.Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal.transnsduction[J].J Biol Chem,1997,272:971-976.

共引文献243

同被引文献151

引证文献12

二级引证文献63

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部