摘要
为了优化反相悬浮法合成交联淀粉微球(CSM)的工艺,采用响应曲面法分析了交联剂质量分数(X1)、反应温度(X2)和引发剂浓度(X3)对于CSM溶胀度和平均粒径的影响,建立预测模型。方差分析表明,X1、X2和X3对于CSM品质具有极显著的影响。较优工艺参数为:X1为0.5%,X2为48℃,X3为3.7 mmol/L,对应的CMS溶胀度及平均粒径的预测值分别为246%和16.5μm,与实验值接近,表明应用响应曲面法所得到的CMS合成工艺参数是可行的,将CSM用于盐酸阿霉素(DOX.HCl)的包载,显示良好的缓释效果。
The response surface methodology was employed to analyze the effects of dosage of crosslinking agent, temperature and initiator concentration on the starch microspheres CSM to derive optimum conditions swelling ratio and the partical size of crosslinked for oreoaration of CSM. And the prediction model was established. The optimum conditions were as follows： amounts of crosslinking agent 0.5%, reaction temperature 48℃ and initiator concentration 3.7 mmol/L. Values predicted by the models for the rate of swelling ratio and the partical size of CSM under optimized conditions were 246% and 16.5μm, respectively. These values were experimentally verified, and the predicted values were good agreement with experimental values. And then CSM was used to encapsulate DOX · HCl which showed good performance in drug release test.
出处
《应用化工》
CAS
CSCD
2011年第9期1512-1515,共4页
Applied Chemical Industry
基金
国家自然科学基金资助项目(50573046)
陕西科技厅社会发展攻关项目(2010K17-04-01)
关键词
淀粉微球
响应面法
DOX·HCl
crosslinked starch microspheres（ CSM）
response surface methodology
DOX · HCl
