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非达霉素 被引量:1

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摘要 非达霉素(fidaxomicin)于2011年5月27日获得FDA批准在美国上市,商品名为Dificid。该药物主要用于治疗艰难梭菌(Clostridium difficile,又名难辨梭状芽孢杆菌)相关性腹泻(CDAD)[1]。非达霉素是近年来由Op-timer制药公司研发的一种新型窄谱的大环内酯类抗菌药。
作者 张兰 胡春
机构地区 沈阳药科大学
出处 《中国药物化学杂志》 CAS CSCD 2011年第5期414-414,共1页 Chinese Journal of Medicinal Chemistry
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  • 1US FDA. FDA approves treatment for Clostridium difficile in- fection [ EB/OL ]. [ 2011 - 05 - 27 ]. http://www, fda. gov/ NewsEvents/Newsroom/PressAnnouncements/ucm257024. htm.
  • 2CH1U Y H,CHE T M,ROMERO A,et al. Polymorphic crystalline forms of tiacumicin B : US, 7378508 [ P ]. 2008 - 05 - 27.
  • 3LOUIE T J, MILLER M A, MULLANE K M, et al. Fidaxomicin versus Vancomycin for Clostridium difficile infection [ J ]. N Engl J Med,2011,364(5 ) :422 -431.
  • 4JOHNSON A P. New antibiotics for selective treatment of gastrointestinal infection caused by Clostridium difficile [ J ]. Expert Opin Ther Pat,2010,20(10) :1389 - 1399.

同被引文献10

  • 1Kelly CP,Pothoulakis C, LaMont JT. Clostridium difficile coli- tis. N Engl J Med[J]. 1994,330 : 257-262.
  • 2Riggs MM, Sethi AK, Zabarsky TF, et al. , Asymptomatic carri- ers are a potential source for transmission of epidemic and nonepi- demic Clostridium difficile strains among long term care facilityresidents. Clin Infect Dis[J]. 2007,45: 992-998.
  • 3Kathleen MM,Sherwood G. Fidaxomiein: first in class macrocu clic antibiotic[J]. Expert Rev Anti Infect Ther, 2011,9 (7) : 767 -777.
  • 4Parenti F, Pagani H, Beretta G. Lipiarmycin, a new antibiotic from ActinoDlanes. I. Description of the producer strain and fer- mentation studies[J]. J Antibiot (Tokyo) ,1975,28(4) :247-252.
  • 5Coronelli C,Parenti F,White R,et al. Lipiarmyein and its prepa ration[P]. US:03978211,1976-08-31.
  • 6Theriault RJ ,Karwowski JP,Jackson M,et al. Tiaeumicins,a no vel complex of 18-membered macrolide antibiotics. I. Taxonomy,fermentation and antibacterial activity[J]. J Antibiol (Tokyo) 1987,40(5) :567-574.
  • 7Michael G,Grit A. OPT-80,a macrocyclic antimicrobial agent for the treatment of Clostridium difficile infections: a review[J]. Expert Opin Investig Drugs, 2008,17(4) : 547-553.
  • 8Shue YK, Du CJF, Chiou MH, et al. Tiacumicin production[ P]. US: 7507564,2009-03-24.
  • 9Credito KL, Appelbaum PC. Activity of OPT-80,a novel macro cycle,compared with those of eight other agents against selected anaerobic species[J]. Antimicrob Agents Chemother, 2004,48 (11) :4 430-4 434.
  • 10姜春梅,刘洋,王京晶,张清,康博欣.抗感染新药非达霉素的药理作用与临床评价[J].中国新药杂志,2011,20(23):2283-2285. 被引量:17

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