摘要
目的:系统评价益气养阴活血法联合ACEI或ARB类药物对早期2型糖尿病肾病的疗效。方法:全面收集并纳入符合标准的文献,按Cochrane协作网肾脏病组的质量评价标准评价纳入研究的方法学质量,提取有效数据并采用Revman 5.0软件进行分析。结果:共纳入16个RCT,包括1159例早期2型糖尿病肾病患者,但方法学质量评价显示纳入研究质量不高,仅有2个B级,其余14个均为C级。Meta分析显示:与单用ACEI或ARB类药物相比,益气养阴活血法联用ACEI或ARB类药物在改善早期2型糖尿病肾病患者某些指标方面具有优势,仅有1个文献报道试验组有2例、对照组1例出现干咳,未见其他不良反应。结论:与单用ACEI或ARB类药物相比,益气养阴活血法联合ACEI或ARB类药物有更好的疗效且相对安全。对这些结果的解释应持谨慎的态度,期待更多高质量的随机双盲对照试验提供高质量的证据。
Objective： To evaluate the effectiveness of ACEI or ARB combination with supplementing Qi,nourishing Yin and vivifying blood flow on type 2 of Incipient Diabetic Nephropathy.Methods： The literature research about type 2 of Incipient Diabetic Nephropathy was identified and assessed according to the Cochrane Handbook for Systematic Reviewsof Interventions,and then Revman 5.0 was used to undertake meta analysis.Results：Sixteen RCTs of 1159 patients of incipient diabetic nephropathy were included.Two trials were classified as grade B,others were classified as grade C.The results of meta.analysis demonstrated that compared with ACEI or ARB alone,combination with the Traditional Chinese Medicine（TCM） of supplementing Qi,nourishing Yin and vivifying blood flow could significantly decreased some indexes of type 2 of Incipient Diabetic Nephropathy.Only one trail reported that two patients of the experimental and one patient of the control suffered from dry cough.Conclusion：Comparing with ACEI or ARB alone,combination with the Traditional Chinese Medicine（TCM） of supplementing Qi,nourishing Yin and vivifying blood flow has some effect and is relatively safe in treating patients with type 2 of Incipient Diabetic Nephropathy,but the evidence is insufficient to determine the effectiveness.Further large-scale trials are required to define the role of supplementing Qi,nourishing Yin and vivifying blood flow in the treatment of type 2 of Incipient Diabetic Nephropathy.
出处
《中华中医药学刊》
CAS
2011年第10期2233-2236,共4页
Chinese Archives of Traditional Chinese Medicine
基金
广东省"211工程"三期重点学科建设项目(200901)
