红花黄色素对氧自由基引起人红细胞膜损伤的保护作用

Protective Effect of Safflor Yellow on Damage of Erythrocyte Membrane by Oxygen Free Radicals

目的:研究羟基红花黄色素A(HSYA)和红花黄色素B(SYB)对超氧阴离子自由基(O2-.)引发的人红细胞膜氧化损伤的保护作用。方法:采用邻苯三酚制备人红细胞膜过氧化损伤模型,研究HSYA和SYB对人红细胞膜氧化损伤的影响。结果:O2-.能引起红细胞膜脂质过氧化,使膜流动性下降。而红细胞膜经过一定量的HSYA和SYB预处理后,膜流动性提高。结论:HSYA和SYB对氧自由基引发的红细胞膜损伤具有一定的保护作用。

Objective：To study the protective effect of hydroxysafflor yellow A（HSYA）and safflor yellow B（SYB）on the oxidative damage of erythrocyte membrane.Methods：Oxidative damage of the erythrocyte membrane induced by superoxide anion（O2-.）from the auto-oxidation of pyrogallic acid was used as model.The effect of HSYA and SYB on oxidated erythrocyte membrane was observed.Results：O2-.caused lipid peroxidation of erythrocyte membrane and decreased membrane fluidity.However,pretreatment with HSYA and SYB respectively could improve the membrane fluidity.Conclusion：HSYA and SYB have protective effect on the oxidative damage of erythrocyte membrane induced by O2-..