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1,2,3-三氮唑衍生物的合成及其抑制幽门螺杆菌活性研究 被引量：1

Studies on the Synthesis and Anti-Helicobacter Pylori Activity of 1,2,3-Triazole Derivatives
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摘要 设计并合成了15个未曾见文献报道的1-(2-(4-取代)苯氧乙基)-1H-1,2,3-三氮唑衍生物,并通过NMR、IR、MS确认了它们的结构.对合成条件进行了探讨,得出了叠氮化的最佳合成条件:卤代烃/叠氮化钠摩尔比为1:1.5,反应温度为65℃,幽门螺旋杆菌(HP)体外抑制活性测试结果表明,化合物4c、5d、5k、5l对1 6株HP表现出一定的抑制活性. Fifteen unknown 1-（2-（4-subsitituted）phenyloxyethyl）-1,2,3-triazole derivatives winthout recorded report were synthesized,their structures were confirmed by NMR,IR,and MS.Synthetic conditions were discussed,the optimum reaction conditions were obtained as follows： n（RX）：n（NaN3）=1：3,reaction temperature 65℃.The preliminary results against Helicobacter pylori（HP） indicated that four compounds 4c,5d,5k and 5l could show a high antibacterial activity against HP.
作者 吴凤艳 陈昌红 彭立望
机构地区 邵阳学院生物与化学工程系
出处 《邵阳学院学报（自然科学版）》 2011年第3期58-62,共5页 Journal of Shaoyang University：Natural Science Edition
基金 湖南省大学生研究性学习和创新性实验计划项目资助(湘教通[2010]244-320)
关键词 1 2 3-三氮唑 合成 幽门螺旋杆菌 1 2 3-triazole synthesis helicobacter pylori
分类号 R914.5 [医药卫生—药物化学]
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参考文献11

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  • 9成兰兴,师传兴.1H-1,2,3-三氮唑合成新工艺[J].广东化工,2011,38(1):65-65. 被引量：1
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二级参考文献4

同被引文献7

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  • 4Rowsell,J.L.C.,Yaghi,O.M.Effects of functionalization,catenation,and variation of the metal oxide and organic linking units on thelow-pressure hydrogen adsorption properties of metal-organic frameworks[J].J.Am.Chem.Soc.,2006,128:1 304-1 315.
  • 5Rowsell,J.L.C.,Spencer,E.C.,Eckert,J.,et al.Gas adsorption sites in a large-pore metal-organic framework[J].Science,2005,309:1 350-1 354.
  • 6刘进兵,张春霞,李秀玲,林崇懒,宋化灿.1-(2-(4-取代)苯氧乙基)-1H-1，2，3-三氮唑衍生物的合成及其抗菌活性研究[J].中山大学学报（自然科学版）,2008,47(2):65-68. 被引量：3
  • 7钟霞,刘雯清.Schiff碱金属配合物研究进展[J].海南医学院学报,2010,16(11):1524-1527. 被引量：3

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邵阳学院学报（自然科学版）
2011年 第3期

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