质子转移反应质谱用于痕量挥发性有机化合物的在线分析

Proton Transfer Reaction-Mass Spectrometry for On-line Analysis of Trace Volatile Organic Compounds

质子转移反应质谱(PTR-MS)是一种化学电离源质谱技术,专门用于痕量挥发性有机化合物(VOCs)实时在线检测。此技术利用H3O+作化学电离源试剂离子与作为质子接受体的VOCs发生质子转移反应。大气中的O2,N2,CO2等主要成分由于其质子亲和势低于H2O,而不与H3O+发生质子转移反应,因此可在大气环境下检测痕量VOCs的含量,而不受空气组分的影响。与常规检测VOCs的气相色谱-质谱联用技术(GC-MS)相比,PTR-MS具有测量速度快,灵敏度高,绝对量测量不需要定标,无需复杂的样品前处理等优点。本文全面叙述了质子转移反应质谱仪器的工作原理和结构装置,概括了近年来在质子转移反应质谱仪器设备的改进方面所取得的进展,并介绍了其在空气环境监测,食品检测及医学诊断等领域中的应用。

Proton transfer reaction mass spectrometry（PTR-MS） is a technique developed almost exclusively for the detection of volatile organic compounds（VOCs）.By using H3O＋ as the reacting agent,proton transfer reaction with proton acceptor VOCs can be obtained.Most of the common inorganic constituents of air possess proton affinities lower than that of H2O and,therefore,can not react with H3O＋.Consequently,PTR-MS can be used to detect trace VOCs in the environment at atmospheric conditions without interference from air.Compared to gas chromatography-mass spectrometry（GC-MS）,PTR-MS has some significant advantages such as fast response time,high sensitivity,Absolute measurements,and simple preparation for samples,thus making it the preferred method for VOC detection.In this review,we briefly introduced the principles and apparatus of PTR-MS.Moreover,we also discussed the development of PTR-MS,with special focus on domestic PTR-MS,and gave some typical example applications of PTR-MS in the fields of environmental science,food,and medical diagnostics.