清热滋阴活血方剂用于2型糖尿病伴牙周炎患者疗效观察

Curative effect of Qingreziyinhuoxue recipe on type 2 diabetic mellitus patients with periodontitis

目的探讨清热滋阴活血方剂对2型糖尿病(T2DM)伴牙周炎的治疗效果。方法采用随机双盲法将84例T2DM伴牙周炎患者分为观察组及对照组各42例。两组均予牙周基础治疗,在此基础上观察组口服清热滋阴活血方剂2个月。治疗前后测定6颗受检牙6个位点菌斑指数(PLI)、龈沟出血指数(SBI)、探诊深度(PD)、附着丧失(AL)等牙周临床指标及龈沟液中IL-6水平。结果两组治疗后各项牙周指标均明显改善(P均<0.01),龈沟液中IL-6水平明显降低(P<0.05);观察组SBI、PD、AL及龈沟液IL-6改善程度明显好于对照组(P<0.05)。结论清热滋阴活血方剂用于T2DM伴牙周炎可明显提高牙周基础治疗的效果;其机制可能为降低龈沟液中IL-6水平。

Objective To investigate the clinical effect of Qingreziyinhuoxue recipe on type 2 diabetic mellitus （T2DM） patients with periodontitis. Methods Eighty-four cases of periodontitis with T2DM were randomly divided into observed group and control group with 42 in each. The two groups were both given periodontal initial therapy, the observed group was given Qingreziyinhuoxue recipe for 2 months, in addition. Then the plaque index（PLI） , sulcus bleeding index （SBI）, probing depth （PD） and attachment loss （AL）were recorded, and levels of IL-6 in GCF were measured before and after treatment. Results After treatment, all indexes of two groups improved obviously（ all P 〈 0.01 ）, and level of IL-6 in gingival crevieular fluid （GCF） decreased obviously（P 〈0.05） ; the changes of SBI, PD, AL and IL-6 in GCF in the observed group were significantly better than those in the control group （P 〈 0.05 ）. Conclusions Qingreziyinhuoxue recipe can improve the curative effect of periodontal initial therapy on periodontitis with T2DM; the mechanism maybe reduce the level of IL-6 in GCF.