阿尔茨海默病患者尿甲醛浓度与MMSE的相关性

Correlation of urine formaldehyde levels and mini mental state examination scores in Alzheimer's disease

目的比较65岁以上正常老人和阿尔茨海默病(AD)患者尿液甲醛浓度,并对不同程度AD患者尿液甲醛浓度与简短精神状态量表(MMSE)分数相关性进行分析。方法经筛查健康老人30例为正常组,AD的诊断采用世界卫生组织制订的国际疾病分类第10版(ICD-10)的标准。选用MMSE和临床痴呆评定(CDR)等量表进行认知功能评估。确定为AD患者后,再按MMSE得分高低将AD患者分成轻、中、重三组,每组30例。留取早晨空腹中段尿液20 ml备检。结果正常组与AD患者尿液甲醛浓度有明显差异(rs=-0.676,P<0.001)。MMSE分值在20～26分之间到轻度AD患者组(rs=-0.195)与正常组(rs=-0.173)中,尿液甲醛含量与MMSE分数无相关性(P>0.05)。MMSE分值在10～19分之间的中度AD患者组(rs=-0.467)和MMSE分值在0～9分之间的重度AD患者组(rs=-0.362),尿液甲醛含量与MMSE分数呈成负相关,均有统计学意义(P<0.05)。结论 AD患者尿甲醛浓度显著高于正常老年人,而且中、重度AD患者的尿甲醛浓度与MMSE分数负相关。提示尿甲醛浓度可能成为AD临床诊断的一项有用的生物学指标。

Objective To investigate the correlation of endogenous formaldehyde in urine of elderly patients of Alzheimer＇s disease（A D） and mini mental state examination（MMSE） scores. Methods Urine formaldehyde level was analyzed by high-pe rformance liquid chromatography（with fluorescence detection） from patients with mild,moderate,and severe AD（aged 65 and over）,and age-matched healthy indi viduals（n=30 for each group）. Results Urine formaldehyde level was inversely correlated with MMSE scores（rs=-0.676,P0.001）,with a marked elevation in pa tients with severe dementia and slight increase in moderate cases. Conclusions Urine formaldehyde level is probably related to cognitive impairments,and might be a potential diagnosis index for AD.