妊娠中期补充锌钙与产时脐血铅、镉水平的关系分析

Relationship between compound preparation of zinc and calcium and umbilical blood cadmium and lead levels in second-trimester pregnant women

目的研究妊娠中期补充锌钙与脐带血锌、钙、铅、镉含量的相关关系。方法 研究组150例孕妇于妊娠20~27＋6周口服葡萄糖酸锌钙口服液（锌钙特）15 d,与对照组150例孕妇比较脐带血锌、钙、铅、镉含量,并分析其与孕中期血锌、钙含量的相关关系。结果口服葡萄糖酸锌钙口服液后,妊娠中期孕妇血锌、钙含量明显高于口服前和对照组,孕妇口服锌钙特前后血铅、镉含量无明显变化。研究组分娩后脐血锌[（9.87±3.22）μmol/L vs（6.95±2.78）μmol/L,t=8.41,P〈0.05]、钙含量[（1.59±0.41）mmol/L vs（1.43±0.38）mmol/L,t=3.51,P〈0.05）]均值高于对照组;铅[（0.15±0.13）μmol/L vs（0.19±0.12）μmol/L,t=2.77,P〈0.05）]、镉[（1.43±0.68）μg/L vs（1.68±0.64）μg/L,t=3.28,P〈0.05）]含量均值明显低于对照组。结论孕中期母体补充锌、钙可以增加脐血锌、钙含量,降低脐血铅、镉水平。

Objective To survey the relationship between compound preparation of zinc and calcium and umbilical blood cadmium and lead levels in second-trimester pregnant women.Methods 150 pregnant women（study group） taken calcium and zinc gluconates solution orally at 20 weeks to 27＋6 weeks of gestational age.The umbilical blood cadmium,lead,zinc and calcium levels were tested and compared to those of 150 control pregnant women.Results After prescription of zinc and calcium,the blood levels of zinc and calcium were higher than that of before prescription and control group.The blood levels of cadmium and lead in study group had no significant change before and after prescription.The average levels of umbilical blood zinc and calcium in study group were higher than that in control group {Zinc（9.87±3.22）μmol/L vs（6.95±2.78） μmol/L,t=8.41,P0.05）],{（calcium（1.59±0.41）mmol/L vs（1.43±0.38）mmol/L,t=3.51,P0.05）],whearase the levels of lead and cadmium were lower {lead（0.15±0.13）μmol/L vs（0.19±0.12）μmol/L,t=2.77,P0.05],{cadmium（1.43±0.68）μg/L vs（1.68±0..64） μg/L,t=3.28,P0.05}.Conclusions Prescription of compound preparation of zinc and calcium in second-trimester pregnant women could increase the level of neonatal blood zinc and calcium,and meanwhile could reduce the level of neonatal blood cadmium and lead.