鼠疫菌对抗生素的敏感性综合评价

Comprehensive evaluation of the sensitivity of Yersinia pestis to antibiotics

目的建立鼠疫菌对抗生素敏感性综合评价方法，并用该方法就鼠疫菌对6种抗生素的敏感性进行综合评价。方法通过查阅文献，收集鼠疫菌对抗生素敏感性实验数据，以抗生素对强毒141菌株、弱毒EV，嘶。菌株和云南分离菌株的抑菌情况，即抑菌环直径作为评价指标，用层次分析法综合评价鼠疫菌对所选6种抗生素（头孢他啶、氨苄青霉素、头孢唑啉、环丙沙星、诺佛沙星、链霉素）的敏感性。结果鼠疫菌对不同抗生素的敏感性存在差异，鼠疫菌对所选6种抗生素的敏感性由高到低依次为头孢他啶、氨苄青霉素、头孢唑啉、环丙沙星、诺佛沙星、链霉素，综合评分指数分别为1．73077、1．63177、1．58195、1．56780、1．44948、0．99999。结论运用层次分析法评价鼠疫菌对不同抗生素的敏感性可以取得合理、客观和较为准确的评价结果．可以利用该方法及其评价结果为进一步筛选适宜的鼠疫治疗药物提供参考依据。

Objective To establish a comprehensive evaluation method on sensitivity of Yersinia pestis to different antibiotics, then use the method to evaluate the sensitivity of Yersinia pestis to 6 antibiotics. Methods Through literature review, related articles were consulted and sensitivity testing data to antibiotics were collected, and the sensitivity of Yersinia pestis to the 6 antibiotics was assessed with analytic hierarchy process. The sensitivity of Yersinia pestis to the 6 antibiotics （Cefotaxime penicillin, Ampicillin, Cefazolin, Ciprofloxacin, Ciprofloxacin Buddha＇s, and Streptomycin） was evaluated comprehensively with analytic hierarchy process from the antibacterial situation of the antibiotics to Yersinia pestis of 141 strains of virulent, attenuated EV71 strains and isolates of the bacteria of Yunnan. Results The evaluation showed that the sensitivity of Yersinia pestis to antibiotics was different. The rank of the sensitivity of Yersinia pestis to the 6 antibiotics was： Ceftazidime, Ampicillin, Cefazolin, Ciprofloxacin, Norfloxacin and Streptomycin. Composite score index were 1.730 77, 1.631 77, 1.581 95, 1.567 80, 1.449 48, and 0.999 99, respectively. Conclusions Analytic hierarchy process evaluation can be a reasonable, objective and more accurate evaluation on the sensitivity of Yersinia pestis to different antibiotics. This method could provide some references for screening feasible pharmaceuticals against plague.