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组蛋白去乙酰化酶6在阿尔茨海默病中的作用 被引量：4

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摘要 组蛋白去乙酰化酶6(HDAC6)是HDAC家族中Ⅱb类成员之一,具有去乙酰化酶活性和参与细胞内异常蛋白降解的功能。近来研究发现HDAC6参与调节Tau蛋白磷酸化、糖原合成酶激酶3β(GSK3β)影响线粒体运输等有关的生化过程,提示HDAC6可能与AD的发生有关,是治疗AD的潜在靶点。本文论述了HDAC6的结构与功能、HDAC6的选择性抑制剂以及在AD中的作用。
作者 陆剑平 朱元贵 陈晓春
机构地区 福建医科大学附属协和医院神经内科福建省老年医学研究所 福建省高校脑老化与神经变性疾病重点实验室福建医科大学神经生物学研究中心
出处 《国际神经病学神经外科学杂志》 2011年第4期348-352,共5页 Journal of International Neurology and Neurosurgery
基金 国家自然科学基金(81071007) 福建省自然科学杰出青年基金(2009J06015)
关键词 组蛋白去乙酰化酶6 阿尔茨海默病 TAU蛋白 糖原合成酶激酶3Β 异常蛋白包涵体
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献28

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同被引文献40

  • 1秦永伟,程纯,王海波,高永静,邵晓轶,沈爱国.P38在LPS诱导大鼠雪旺氏(Schwann)细胞TNF-α表达中的作用[J].中国生物化学与分子生物学报,2007,23(5):382-387. 被引量：5
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  • 6Hye A, Kerr F, Archer N, et al. Glycogen synthase kinase- 3 is increased in white ceils early in Alzheimer' s disease. Neurosci Lett, 2005, 373(1) : 1-4.
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  • 10Zhou X, Zhou J, Li X. GSK-313 inhibitors suppressed neu- roinflammation in rat cortex by activating autophagy in ischemic brain injury. Biochem Biophys Res Commun, 2011 , 411 (2) : 271-275.

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国际神经病学神经外科学杂志
2011年 第4期

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