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中枢神经系统小胶质细胞的研究进展 被引量：3

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摘要 中枢神经系统(CNS)中的小胶质细胞源于造血系统,是CNS的胶质细胞,又有着单核吞噬细胞的属性。在正常情况下,它对周围神经组织起着连续监视作用以维持CNS的稳态,小胶质细胞微小的异常也会引起机体的功能障碍;而当疾病或损伤发生时,失去了神经元的抑制作用,活化后的小胶质细胞作为CNS中的定植炎症细胞参与炎症反应与免疫应答。
作者 李师君 毛定安
机构地区 中南大学湘雅二医院儿科
出处 《国际神经病学神经外科学杂志》 2011年第4期374-377,共4页 Journal of International Neurology and Neurosurgery
关键词 小胶质细胞 中枢神经系统 起源 免疫反应
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献20

  • 1McKercher SR, Torbett BE, Anderson KL, et al. Targeted disruption of the PU. 1 gene results in multiple hematopoietic abnormalities. EMBO, 1996, 15(20) : 5647-5658.
  • 2Man S, Ubogu E E, Ransohoff RM. Inflammatory cell migra- tion into the central nervous system: a few new twists on an old tale. Brain Pathology, 2007, 17(2) : 243-250.
  • 3Ashwell K. The distribution of microglia and cell death in the fetal rat forebrain. Brain Research. Dev Brain Res, 1991 , 58(1): 1-12.
  • 4Wu HH, Bellmunt E, Scheib JL, et al. Glial precursors clear sensory neuron corpses during development via Jedi-1 , an engulfment receptor. Nat Neurosci, 2009, 12 ( 12 ) : 1534-1541.
  • 5Caldero J, Brunet N, Ciutat D, et al. Development of mi- croglia in the chick embryo spinal cord: implications in the regulation of motoneuronal survival and death. Neuroscience, 2009, 87 ( 11 ) : 2447 -2466.
  • 6Neumann H, Takahashi K. Essential role of the microglial triggering receptor expressed on mydoid cells-2 (TREM2) for central nervous tissue immune homeostasis. Neuroimmunol- ogy, 2007, 184(1-2) : 92-99.
  • 7Chouery E, Delague V, Bergougnoux A, et al. Mutations in TREM2 lead to pure early-onset dementia without bone cysts. Hum Mutat, 2008, 29(9) : E194-E204.
  • 8Thrash JC, Torbett BE, Carson MJ. Developmental Regula- tion of TREM2 and DAP12 Expression in the Murine CNS: Implication of Nasu-Hakola Disease. Neurochem Res, 2009, 34(1): 38-45.
  • 9Amor S, Puentes F, Baker D, et al. Inflammation in Neuro- degenerative Diseases. Immunology, 2010 , 129 ( 2 ) : 154 - 169.
  • 10Reed-Geaghan EG, Savage JC, Hise AG, et al. CD14 and Toll-like receptors 2 and d are required for fibrillar AIS-stimu- lated microglial activation. Neuroscience, 2009, 29 ( 9 ) : 11952-11992.

同被引文献68

  • 1杜景卫,夏作理.小胶质细胞与缺血性脑损伤[J].中国临床康复,2005,9(25):168-169. 被引量：4
  • 2史晓萍,宗阿南,陶钧,王禄增.《关于善待实验动物的指导性意见》的研究[J].中国医科大学学报,2007,36(4):493-493. 被引量：72
  • 3Harry GJ, Kraft AD. Neuroinflammation and microglia: con- siderations and approaches for neurotoxicity assessment[ J ]. Expert Opin Drug Metab Toxicol, 2008,4 ( 10 ) : 1265 - 1277.
  • 4Biber K, Vinet J, Boddeke HW. Neuron - microglia signa- ling : chemokines as versatile messengers [ J ]. J Neuroimmu- nol,2008,198( 1 -2) :69 -74.
  • 5Guire ES. Recruitment of calcium - permeable AMPA re- ceptors during synaptic potentiation is regulated by CaM - kinase I [ J ]. J Neurosci, 2008,28 (23) : 6000 - 6009.
  • 6Taylor DL, Jones F, Kubota ES, et al. Stimulation of microgli- al metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor alpha - induced neurotoxicity in concert with microglial - derived Fas ligand [ J ]. J Neurosci, 2005,25 ( 11 ) :2952 -2964.
  • 7Kuhn SA, van Landeghem FK, Zacharias R, et al. Microglia express GABA(B) receptors to modulate interleukin release [ J ]. Mol Cell Neurosci, 2004,25 (2) : 312 - 322.
  • 8Sperl6gh B, Illes P. Purinergic modulation of microglial cell activation [ J ]. Purinergic Signal, 2007,3 ( 1 - 2 ) : 117 - 127.
  • 9Haynes SE, Hollopeter G, Yang G, et al. The P2Y~2 receptor regulates microglial activation by extracellular nucleotides [J]. Nat Neurosci,2006,9 (12) :1512 - 1529.
  • 10Sasaki Y, Hoshi M, Akazawa C,et al. Selective expression of Gi/o - coupled ATP receptor P2Y12 in microglia in rat brain [ J]. Gila,2003,44(3 ) :242 - 250.

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国际神经病学神经外科学杂志
2011年 第4期

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