Survivin、COX-2蛋白在眼睑基底细胞癌中的表达及意义

Expression and Significance of Survivin and COX-2 in Blepharal Basal Cell Carcinoma

目的:探讨COX-2和Suvrivin蛋白在眼睑基底细胞癌组织中的表达及临床意义。方法:搜集本院病理科2000年1月-2010年12月保存的基底细胞癌标本100例,所有眼睑基底细胞癌肿瘤组织均经病理科检查确诊。同时搜集同期100例正常眼睑部组织,正常对照组100例均为单侧,均来自眼睑松弛症患者。运用免疫组织化学方法检测Survivin蛋白和COX-2蛋白在100例眼睑基底细胞癌中的表达。结果:眼睑基底细胞癌组织中COX-2蛋白呈高表达;正常眼睑组织中COX-2蛋白呈低表达。眼睑基底细胞癌组织中Suvrivin蛋白呈高表达;正常眼睑组织中Suvrivin蛋白呈低表达。两种基因表达均无年龄、性别、生长部位的统计学差异(均P>0.05)。结论:COX-2、Survivin在眼睑基底细胞癌中的高表达,对眼睑基底细胞癌的发生和发展起了重要作用。

Objective：To research the expression and clinical significance of COX-2 and Survivin protein in eyelid basal cell carcinoma.Methods：The specimens of 100 cases of eyelid basal cell carcinoma and 100 normal specimens from floppy eyelid syndrome patients were collected.Immunohistochemical method was adopted to detect the expression of Survivin and COX-2,and the expression results were compared between the two groups.Results：Eyelid basal cell carcinoma showed high COX-2 and Survivin expression,while normal eyelid tissue showed low COX-2 and Survivin expression（both P0.05）.Conclusion：Survivin and COX-2 are highly expressed and play an important role in eyelid basal cell carcinoma.