某高校教工高尿酸血症的现况调查

A Cross-Sectional Study on Hyperuricemia in Faculty of A University

目的:探讨男女性高尿酸血症患病率的差异及其影响因素,为防治措施制定提供科学依据。方法:采用现况调查的方法,以5 804例体检教职工为研究对象,进行问卷调查、体格检查和实验室检测,按高尿酸血症诊断标准将其分为高尿酸血症组和正常尿酸组,按照年龄和性别统计高尿酸血症的患病率,并按照性别分层探讨其危险因素。结果:高尿酸血症患病率为15.0%,男性20.1%,女性7.2%。高尿酸血症组超重、肥胖、高血压、高胆固醇血症、高甘油三脂血脂症、高血糖、尿素偏高的比例显著高于正常组(P<0.05)。按性别分层进行多因素分析,男性中高尿酸血症的危险因素包括超重/肥胖和高甘油三酯血症,而女性为超重/肥胖、尿酸偏高、高胆固醇血症、高甘油三酯血症。结论:男女性高尿酸血症的患病率有较大差异,超重/肥胖和高甘油三酯血症为其共同的危险因素,具有该危险因素的高校教职工为高尿酸血症防治的重点人群。

Objective：To assess the prevalence of hyperuricemia and its risk factors among faculty members in one university of Wuhan.Methods：A population of 5 804 faculty were selected as the subjects,interviewed with questionnaire and conducted physical examination and laboratory examination.According to diagnostic criteria of hyperuricemia,the subjects were divided into case and control groups respectively.Results：The overall prevalence for hyperuricemia in the studied population was 15.0%,and it was significantly higher in men as compared to women（20.1% vs 7.2%,P0.001）.The frequency of overweight,obesity,hypertension,hypercholesterolemia,hypertriglyceridemia,hyperglycosemia,and high blood urea nitrogen in case group was higher than that respectively in control group（all P0.05）.The results of the gender stratified multivariate logistic regression analysis showed that in males,overweight or obesity and hypertriglyceridemia were independent risk factors of hyperuricemia,and in females,another two factors including high blood urea nitrogen and hypercholesterolemia appeared to be independent risk factors of hyperuricemia as well.Conclusion：University faculty menbers with above independent risk factors were susceptive to hyperuricemia,and they are the focus of prevention and control.