肠外营养预混配方与全合一配液配方的临床应用调查

A study on the clinical application of all-in-one-mixed and pre-mixed parenteral nutrition preparations

目的了解国内住院患者全合一肠外营养液与预混肠外营养液的配方特点。方法收集国内6家不同地区医院的配制中心因不同疾病住院患者的肠外营养处方，统计营养素供给量、总液体量、非蛋白质热卡、总氮量、热氮比、糖脂比等指标，并与预混营养液相比较。结果全合一营养液处方中营养素的供给量能够满足患者基本营养需要，不同能量级别的预混营养液基本能够满足大多数住院患者的营养需要。全合一营养液处方中总氮量基本能够满足患者营养需要，但热氮比[（180～250）：1]、糖脂比（0．56～1．26）与推荐值[（100～150）：1，1．0]差距较大，而3种不同能量级别的预混营养液中的热氮比（167）、糖脂比（0．8）更为理想。结论全合一营养液和预混营养液各有优缺点，能满足多数住院患者疾病治疗的需要。全合一营养液处方应多考虑营养素分配比例的问题。

Objective To evaluate the parenteral nutrition formula＇s character of all-in-one-mixed preparation and pre-mixed preparation applied for hospitalized patients in China. Methods We collected parenteral nutrition （PN） prescriptions in hospitalized patients with various diseases at dispensing centers of 6 hospitals in different areas of China. Statistic analysis was made by nutrients application, total liquid, nonprotein calories, total nitrogen, ratio of non-protein calories and total nitrogen, and ratio of glucose and fat. A comparison was made between all-in-one-mixed and pre-mixed preparation as to all the indices. Results The nutrients supply in all-in-one-mixed PN preparation, as well as in the pre-mixed PN preparations of 3 different energy degrees can meet the basic nutrition requirements of most patients. The total nitrogen supply in all-in-one-mixed PN prescriptions meets nutrition requirements in most patients, but the ratio of non-protein calories and total nitrogen [ （ 180 - 250） ： 1 ] and the ratio of glucose and fat （0. 56 - 1.26） were significantly different from what a doctor would recommend [ （100 - 150）： 1, 1.0]. While the ratios in the pre-mixed PN preparation on 3 different energy degrees are more consistent with recommeded values, which are at 167 and 0. 8 respectively. Conclusions All-in-one-mixed and pre-mixed PN preparation have their own individual advantages and limits, and both of them can meet the requirements of most hospitalized patients. More attention should be paid to the nutrients proportion when doctors prescribe all-in-one-mixed PN preparations.