MEF2D在鼻咽癌组织中的表达以及与预后的关系

Expression of MEF2D on nasopharyngeal carcinoma tissues and its influence of prognostic

目的:观察MEF2D在鼻咽癌组织中的表达,结合鼻咽癌患者的1～7年的随访资料,探讨MEF2D在鼻咽癌早期转移、预后方面的作用。方法:选取鼻咽癌患者的鼻咽部标本101例,免疫组织化学检测MEF2D在组织中的蛋白表达,并进行差异性分析、生存分析。结果:①在鼻咽癌的4个临床分期中,MEF2D的表达具有统计学差异:临床分期越高,MEF2D表达阳性水平也升高;②MEF2D的单位吸光度值与灰度呈直线负相关关系(︱r︱=0.865,P<0.01),免疫组织化学分级与灰度值呈直线负相关关系(︱r︱=0.959,P<0.01);③放化疗后的鼻咽癌患者5年生存率为52.5%,在4个临床分期中,1期的生存曲线较4期生存曲线高,有统计学意义(P<0.05);④鼻咽癌标本的MEF2D4个分级中,生存曲线无统计学意义(P>0.05)。结论:MEF2D的表达差异在鼻咽癌患者的临床分期中具有统计学意义,但在其生存曲线分析中无统计学意义,提示MEF2D与鼻咽癌的侵袭、转移性有关,与鼻咽癌患者的预后无明显关联。

Objective： To explore the expression of MEF2D in NPC tissures,study the relationship between the expression and prognostic. Method： Specimens from 101 NPC patients who were follow-up visited 1 to 7 years were analyzed for MEF2D by using immunohistochemistry. Result： ①The expression of MEF2D was higher in the higher clinical stage.②Density and Grey of MEF2D was negative correlated（︱r︱=0.865,P0.01）.③NPC patients＇suvival rate after therapies was 52.5%,the survival curve of 1th clinical stage was higer than 4th.④The survival curves of MEF2D stages were no statistical significance. Conclusion： There＇s statistical significance of the MEF2D expression in clinical stages,but not in survival curve,which indicated that MEF2D concerned with invasion and metastatic of NPC.