垂体瘤转化基因在原发性肝癌中的表达及其与预后不良的关系
摘要
肝癌是全世界范围的高发恶性肿瘤,其发生是多基因、多步骤、多阶段的复杂过程[1]。对于肝癌的发病机制,目前普遍认为与癌基因的激活、抑癌基因的失活及染色体的非整倍体的出现、细胞周期及细胞周期调节点失控关系密切。
出处
《肝脏》
2011年第4期316-318,共3页
Chinese Hepatology
基金
黑龙江省教育厅科研课题(11551296)
参考文献11
-
1Poon D, Anderson BO, Chen I.T, et al. Management of hepatocellular carcinoma in Asia: consensus statement from the Asian Oncology Summit 2009. Lancet Oncot, 2009, 10 : 1111-1118.
-
2Kakar SS. Molecular cloning, genomic organization, and identification of the promoter for the human pituitary tumor transforming gene (PTTG). Gene, 1999,240:317-324.
-
3Ishikawa H, Heaney AP, Yu R, et al. Human pituitary tumor transforming dene induces angiogenesis, j" Clin Endocrinol Metab, 2001,86 : 867-874.
-
4Ramaswamy S, Ross KN, Lander ES, et, al. A molecular signature of metastasis in primary solid tumors. Nat Genet, 2003, 33: 49-54.
-
5Pei L, Melmed S. Isolation and characterization of a pituitary tumor-transforming gene (PTTG). Mol Endocrinol, 1997, 11 : 433-441.
-
6Iwasaki T, Hamano T, Ogata A, et al. Clinical significance of vascular endothelial growth factor and hepatocyte growth factor in multiple myeloma. Br J Haematol, 2002,116 : 796-802.
-
7Akino K, Akita S, Mizuguchi T, et al. A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration. J Surg Res, 2005,129 : 142-146.
-
8Nagy JA, Senger DR. VEGF-A, cytoskeletal dynamics, and the pathological vascular phenotype. Exp Cell Res,2006,10:312 : 538- 548.
-
9Fujii T, Nomoto S, Kasuya H, et al. Overexpression of pituitary tumor transforming gene I (PTTG1) in HCC is associated with angiogenesis and poor prognosis. Hepatology, 2006, 43:1267-1275.
-
10Pei L. Identification of c-myc as a down-stream target for pituitary t umor-transforming gene. J Biol Chem, 2001,276 : 8484-8491.
-
1解丽琼,李智.细胞因子与EB病毒在影响肿瘤发生、演进中的协同作用[J].现代肿瘤医学,2008,16(11):2027-2030.
-
2徐应永.免疫调节点抑制剂治疗恶性肿瘤的一些思考[J].中华肿瘤杂志,2016,38(2):156-159. 被引量：5
-
3李月雅,李凯.Wnt/β-Catenin信号通路对肿瘤干细胞作用的研究进展[J].山东医药,2016,56(9):98-100. 被引量：13
-
4陈双瑜,蒋冠,刘彦群,魏志平.抗CTLA-4单克隆抗体治疗黑素瘤的进展[J].国际皮肤性病学杂志,2012,38(2):84-86.
-
5赵玉洁,袁耀宗.PTEN和Cdx2在溃疡性结肠炎和结直肠癌中的表达[J].胃肠病学,2008,13(12):741-744.
-
6刘芳,黄多美,玛依努尔.尼亚孜.ING1基因及p33 ING1b蛋白的研究进展[J].医学综述,2007,13(2):83-85.
-
7王慧,罗勇.Atrogin-1和MuRF-1在肌肉萎缩中的作用机制及影响因素[J].实用医学杂志,2012,28(11):1921-1922. 被引量：10
-
8万学东,王西明,夏炎枝,段秋红,秦莉,关中宏.软脂酸诱导HepG2细胞胰岛素抵抗及其机理[J].江苏医药,2006,32(1):4-6. 被引量：7
