骨关节炎软骨下骨研究进展

Subchondral bone in osteoarthritis:a review

骨关节炎是最常见的关节疾病,其病理以关节软骨退变、软骨下骨硬化与骨赘形成为特点。目前骨关节炎的始发病理尚不明确,既往许多研究聚焦于关节软骨并认为软骨下骨的改变继发于关节软骨的退变;然而近年研究报道关节软骨下骨低骨密度,尤其是膝骨关节炎的软骨下骨,软骨下骨呈高转换,以及骨吸收抑制剂治疗骨关节炎有效,都提示软骨下骨在骨关节炎的病理机制中具有重要地位。本文就骨关节炎软骨下骨的研究进展做一综述。

Osteoarthritis（OA） is the most prevalent of joint diseases,and its pathology is characterized by the degeneration of cartilage,sclerosis of subchondral bone,and osteophyte formation.Localization of the early lesions of OA has not been clarified,but many researchers have focused on cartilage and have considered that changes in subchondral bone occur subsequently to the degeneration of cartilage.However,a low bone mineral density,particularly in the knee joint with OA,high bone turnover,and efficacy of bone resorption inhibitors for OA have recently been reported,suggesting that subchondral bone plays an important role in the pathogenesis of OA.This review aims to make a conclusion about advancement in research of subchondral bone in osteoarthritis.