尿微量白蛋白、β_2-微球蛋白与血清高敏C反应蛋白联合检测对2型糖尿病早期肾损害价值

Value of combined detection of urinary microalbuminuria,β_2-microglobin and serum high sensitivity C-reactive protein to the diagnosis of early renal damage in patients with type 2 diabetes mellitus

目的探讨尿微量白蛋白(microalbuminuria,MA)、β2-微球蛋白(β2-microglobin,β2-MG)和血清高敏C反应蛋白(high sensitivity C-reactive protein,hs-CRP)与2型糖尿病早期肾损害的关系。方法 116例2型糖尿病患者中,92例无早期肾损害患者为DM组,24例糖尿病肾病患者为DN组,同期35例健康体检者对照组,测定3组尿MA、β2-MG,血清hs-CRP水平,并进行统计学分析。结果 DM组,DN组尿MA、β2-MG,血清hs-CRP水平高于对照组(P<0.05),DN组高于DM组(P<0.05);3项联合检测阳性率明显高于单项检测(P<0.05)。结论尿MA、β2-MG是反映早期糖尿病肾损害的敏感指标,尿MA、β2-MG与血清hs-CRP联合检测可提高对糖尿病肾病早期肾损害的诊断率。

Objective To explore the relationship of urinary microalbuminuria, β2- microglobin and serum high sensitivity C-reactive protein with early renal damage in type 2 diabetes mellitus. Methods The levels of urinary microalbuminuria, β2-mieroglobin and serum high sensitivity C reactive protein were detected in 116 patients with type 2 diabetes mellitus,in which 92 patients were not complicated with diabetic nephropathy （DM group） and 24 patients were complicated with diabetic nephropathy （DN group） and 35 normal controls（control group）. The statistical data were statistically analyzed. Results The levels of urinary microalbuminuria, β2-microglobin and serum high sensitivity C-reactive protein were significantly higher in DM group and DN group than those in control group（P〈0.05）, and were obviously higher in DN group than those in DM group（P〈0.05）. The positive rate of combined detection for early renal damage was 70. 65%, significantly higher than that of the individual testing（P〈0.05）. Conclusion Urinary microalbuminuria and β2--microglobin are sensitive indicators for early renal damage in patients with type 2 diabetic mellitus. The combined detection can improve the diagnostic rate of renal damage