鼻用糖皮质激素治疗兔急性细菌性上颌窦炎的细菌培养观察

Bacteriological study of intranasal corticosteroids in the treatment of experimental acute bacterial maxillary sinusitis in rabbits

目的探讨鼻用糖皮质激素喷雾剂布地奈德(budesonide)对兔急性细菌性上颌窦炎的细菌学的影响。方法健康成年新西兰白兔48只,采用鼻腔置入Merocel高分子膨胀海绵并注入肺炎链球菌的方法建立急性细菌性上颌窦炎模型,10 d后取出鼻腔膨胀海绵,随机分成抗生素治疗组(A组)、抗生素加鼻用激素治疗组(B组)、鼻用激素治疗组(C组)及对照组(D组),每组各12只。分别于治疗2周及4周后每组各处死6只动物,获取上颌窦腔分泌物作普通细菌培养。结果细菌培养结果显示治疗2周后,虽然A、B组上颌窦分泌物细菌培养阳性率低于C、D组,但组间差异无统计学意义(P>0.05)。治疗4周后,A、B组细菌培养阳性率明显低于C、D组,差异有统计学意义(P<0.05),A、B组间差异无统计学意义(P>0.05)。结论鼻用糖皮质激素合并抗生素治疗兔急性细菌性上颌窦炎时,未见影响抗生素的抗菌效果。

Objective To investigate the possible effects of intranasal corticosteroids on the focal bacterial colonization in experimental acute bacterial maxillary sinusitis in rabbits.Methods Acute bacterial maxillary sinusitis was induced in 48 rabbits.They were divided into 4 groups： antibiotic group（group A）,antibiotic and corticosteroid combination group（group B）,corticosteroid group（group C）,and control group（group D）.Six rabbits in each group were sacrificed to obtain secretions from the maxillary sinuses for bacterial culture after they had been treated for 2 or 4 weeks.Results The differences in bacterial culture ratios in groups A and B compared with groups C and D were significant after treatment for 4 weeks（P0.05）,but there was no significant difference in that between groups A and B（P0.05）.Conclusion Intranasal corticosteroids administered with antibiotics do not decrease the effects of antibiotic treatment.