FXYD6蛋白在鼻咽癌组织中的表达

Expression of FXYD6 protein in nasopharyneal carcinoma

目的探讨FXYD6蛋白表达与鼻咽癌(NPC)患者临床病理特征的关系。方法采用免疫组织化学技术检测128例鼻咽癌组织中FXYD6蛋白的表达情况。结果 FXYD6蛋白在鼻咽癌组织中的表达率为84.3%(108/128),其蛋白在正常组中的阳性表达率为5.0%(4/80),两者差异有统计学意义(P<0.01)。FXYD6蛋白在有颈部淋巴结转移组中的表达率为94.2%(65/69),高于无颈部淋巴结转移组72.8%(43/59),两组比较差异有统计学意义(P<0.0 1)。FXYD 6蛋白的表达与NPC的病理组织学分型,临床分期无明显关系(P>0.05)。结论 FXYD6蛋白高表达与NPC颈部淋巴结转移相关,提示FXYD6表达的上调可作为NPC患者预测淋巴结转移的参考指标。

Objective To study the relationship between expression of FXYD6 protein and clinicopathological characteristics of nasopharyngeal carcinoma（NPC）.Methods The expression of FXYD6 protein in 128 samples of NPC was detected with S-P immunohistochemical method.Results The positive expression rate of FXYD6 in all samples was 84.3%（108/128）;the expression rate of FXYD6 in nromal group was 5.08%（1/80） with significant difference（P0.01） between these two groups.The positive rate in samples with cervical lymph node metastasis was 94.2%（65/69）,which was higher than that without cervical lymph node metastasis（72.8%,43/59）（P0.01）.The expression of FXYD6 was not significantly correlated to the histopathological and clinical classification of NPC（P0 05）.Conclusion The enhanced expression of FXYD6 is significantly correlated to the cervical lymph node metastasis in NPC,which means the up-regulation of expression of FXYD6 maybe a prognostic indicator for cervical lymphatic metastasis of NPC.