STAT3、Survivin在胆囊癌中的表达及意义

Significance and expression of STAT3 in survivin primary gallbladder carcinoma

目的探讨胆囊癌中STAT3、p-STAT3和Survivin蛋白表达及其在胆囊癌发生、发展中的意义。方法采用免疫组织化学SP法检测45例胆囊癌及相应45例癌旁胆囊组织、20例慢性胆囊炎组织中STAT3、p-STAT3及Survivin蛋白的表达,并分析其与临床病理特征、预后的关系。结果本组45例胆囊癌组织中STAT3、p-STAT3和Survivin蛋白阳性率分别为66.7%(30/45)、55.6%(25/45)、64%(29/45),明显高于癌旁正常组织(P<0.01)和慢性胆囊炎组织(P<0.01)。在胆囊癌组织中STAT3、p-STAT3的表达与Survivin表达均呈正相关(r=0.558,0.830;P<0.01)。STAT3、p-STAT3和Survivin蛋白的表达与胆囊癌病理组织分级、Nevin分期、有无淋巴结转移和3年生存率有关(P<0.01)。结论 STAT3、p-STAT3、Survivin参与了胆囊癌的发生、发展,可能作为判断胆囊癌转移、预后的临床指标。

Objective To detect the expression of STAT3,p-STAT3 and Survivin in primary gallbladder carcinoma（PGC） and explore its significance in the occurrence and development of PGC.Methods The expression of STAT3,p-STAT3 and Survivin were determined in samples from 45 PGC tissues and corresponding nontumor tissues,20 chronic cholecystitis by immunohistochemistry.The relationship between expressions of these proteins and clinicopathological factors,and its prognosis were analysed.Results The positive rates of STAT3,p-STAT3 and Survivin in 45 PGC tissues were 66.7%（30/45）,55.6%（29/45）and 64%（25/45）respectively,which was significantly higher than those in 45 corresponding PGC nontumor tissues（P0.01） and 20 chronic cholecystitis tissues（P0.01）.The expression of survivin were positively correlated with STAT3（r=0.558,P0.01）,p-STAT3（r=0.830,P0.01）.The expressions of STAT3,p-STAT3 and Survivin were significantly associated with histopathological grades,lymph node metastasis,nevin stages and 3-year survival rate.Conclusion STAT3,p-STAT3 and Survivin may play a vital role in the occurrence and development of PGC.The expressions of STAT3,p-STAT3 or Survivin are the metastatic and prognostic factors in PGC.