非酒精性脂肪性肝病药物治疗进展

The progress of pharmacotherapy in non-alcoholic fatty liver disease

非酒精性脂肪性肝病(NAFLD)是我国肝酶异常和慢性肝病的常见原因之一,其治疗包括控制饮食、运动锻炼和药物治疗。目前,临床上治疗NAFLD的药物包括减肥药、胰岛素增敏剂、抗氧化剂、抑制肾素血管紧张素系统的降压药、调脂药、细胞因子调节剂和具有良好前景的大麻素受体拮抗剂。在此对NAFLD治疗药物的近期发展作一综述。

Non-alcoholic fatty liver disease is one of the common reasons of chronic liver disease and leading liver enzyme abnormally in china.The treatment for NAFLD includes diet control,exercise and pharmacotherapy.At present,the drugs for NAFLD used in clinic include diet pill,insulin sensitizer,antioxidant,antihypertensive drug for suppressing the renin-angiotensin system,lipid-lowering drugs,cytokines-regulator agents the promising agent cannabinoid receptors antagonists.We will review the recent advances about the pharmacotherapy in non-alcoholic fatty liver disease here.