摘要慢性自然杀伤（naturekiller,NK）细胞起源于骨髓造血干细胞,呈大颗粒细胞形态,约占外周血淋巴细胞的5%,主要参与机体的非特异免疫。慢性NK细胞淋巴细胞增多症（chronic NK cell lymphocytosis,CNKL）是一组罕见的异质性疾病,该病病因不明,大部分呈良性、惰性过程,可自行缓解,少数向恶性转化[1]。
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