血管生成素2对良恶性腹水的鉴别诊断价值

Differential Diagnostic Value of Detecting of Angiopoietin-2 in Malignant and Benign Ascites

目的探讨血管生成素-2(Ang-2)对良、恶性腹水的鉴别诊断价值。方法用ELISA法检测82例良性腹水及119例恶性腹水中Ang-2和癌胚抗原(CEA)的含量。结果恶性腹水组Ang-2和CEA含量均高于良性腹水组(均P<0.01),Ang-2对恶性腹水诊断的敏感度、特异度、总准确率、阴性预测值分别为89.9%,96.3%,92.5%,86.8%,其中敏感度、阴性预测值、总准确率均高于CEA(均P<0.05)。结论恶性腹水Ang-2显示一定的组织特异性。Ang-2可作为良、恶性腹水鉴别诊断的高效肿瘤标志物。

Objective To study the differential diagnostic value of detecting of Angiopoietin-2（Ang-2） in malignant and benign ascites.Methods The concentrations of Ang-2 and CEA in synovia of abdominal cavity of patients with benign ascites（n=82） and malignant ascites（n=119） were measured by ELISA technique.Results The concentrations of Ang-2 and CEA in the malignant ascites group were significantly higher than those in the benign ascites group（P 0.01）.The sensitivity,specificity,total accurate rate and negative predictive value of Ang-2 was 89.9%,96.3% and 92.5%,86.8% respectively,and the sensitivity,the negative predictive value and the total accurate rate was significantly higher than those of CEA（P 0.05）.Coclusion Ang-2 in malignant ascites shows a certain histio-specificity.Ang-2 is an useful tumor marker in differential diagnosis of benign and malignant ascites.