摘要
目的探讨支气管激发试验阳性患者的小气道功能特征。方法对226例慢性咳嗽(>8周)患者进行磷酸组织胺支气管激发试验,分别比较阳性和阴性患者的小气道功能。结果 (1)基础最大中期呼气流速占预计值百分比(MMEF%pred)、用力呼气75%、50%、25%肺活量的瞬时流速占预计值百分比(FEF75%pred、FEF50%pred、FEF25%pred)在支气管激发试验阳性组均低于阴性组,差异均具有高度统计学意义(均P<0.01)。(2)小气道功能障碍组激发试验阳性率高于小气道功能正常组(48%vs 27.8%),两组差异有统计学意义(P<0.05)。(3)以基础MMEF%pred、FEF75%pred、FEF50%pred、FEF25%pred作ROC曲线,ROC曲线下面积分别为66.1%、65.9%、63.8%、59.5%,均小于70%(均P<0.05)。结论基础小气道功能障碍与激发试验阳性率密切相关,且对激发试验阳性率有一定的预测价值,但预测价值较低。
Objective To study the small airway function features of the patients whose bronchial provocation tests were positive.Methods A total of 226 patients with chronic cough(8 weeks) underwent bronchial provocation tests and comparison of all of the small airway functions in the subjects were conducted between the negative group and the positive group.Results(1) There was a significant difference in pulmonary function tests parameters(MMEF% pred、 FEF75% pred、FEF50% pred、FEF25% pred)between the positive group and the negative group(P0.01).(2) The positive rate of the bronchial provocation tests in the small airway dysfunction group was 48%,which was much higher than that in the normal group(27.8%)(P0.05).(3) The area under the ROC curve of the basic MMEF% pred、 FEF75% pred、FEF50% pred、FEF25% pred was 66.1%、65.9%、63.8% and 59.5% respectively(P0.05).Conclusion Decline of the basic functions of the small airway may be related to the positive rate of bronchial provocation tests,and there is a certain value to predict the positive rate of bronchial provocation tests,but the value is low.
出处
《苏州大学学报(医学版)》
CAS
北大核心
2011年第4期631-634,共4页
Suzhou University Journal of Medical Science
关键词
支气管激发试验
小气道功能
气道反应性
bronchial provocation test
small airway function
airway responsiveness