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新辅助化疗对乳腺癌HIF-1α和VEGF-C表达的影响 被引量：2

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摘要 目的:分析乳腺癌新辅助化疗中HIF-1α和VEGF-C表达的变化,探讨其发生机制。方法:应用免疫组织化学法检测51例新辅助化疗组和106例对照组中乳腺癌组织标本HIF-1α和VEGF-C的表达。结果:新辅助化疗组和对照组乳腺癌组织中HIF-1α和VEGF-C的表达差异显著(P<0.05),分别由对照组的42.45%和50.94%,下调到23.53%和33.33%。新辅助化疗组和对照组乳腺癌组织中HIF-1α和VEGF-C的表达呈正相关(P<0.05)。结论:新辅助化疗通过抑制乳腺癌组织中HIF-1α和VEGF-C表达,抑制乳腺癌细胞的浸润和转移。
作者 吕宝军 邹劲林 王晓鸿 苟新敏
机构地区 中山大学附属第五医院甲状腺 中山大学附属第五医院病理科
出处 《北方药学》 2011年第9期40-41,共2页 Journal of North Pharmacy
关键词 乳腺肿瘤 新辅助化疗 缺氧诱导因子-1Α 血管内皮生长因子C
分类号 R737.9 [医药卫生—肿瘤]
  • 相关文献

参考文献5

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共引文献5

同被引文献27

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引证文献2

二级引证文献9

北方药学
2011年 第9期

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