乌鲁木齐周边地区不同民族肥胖儿童血清Leptin水平及其相关因素分析

The analysis of Serum Leptin levels and relative factors in obese children in different ethnics in Urumqi surrounding areas

目的 了解新疆乌鲁木齐周边地区学龄儿童瘦素（Leptin）水平与肥胖的关系及民族、性别和胰岛素水平对Leptin水平的影响。方法对新疆乌鲁木齐周边地区数所小学采取整群抽样方法,抽取291名6~13岁儿童,测量身高、体重,用公式体重（kg）/身高2（m2）计算BMI,采用放射免疫法测定Leptin和胰岛素浓度。结果 （1）肥胖/超重组儿童BMIbLeptin均值及胰岛素水平均高于非肥胖组,差异有统计学意义（P〈0.01）。（2）肥胖/超重组女性Leptin均值高于男性,差异有统计学意义（P=0.048）;非肥胖组女性Leptin均值高于男性,差异有统计学意义（P=0.014）。（3）不同民族学龄儿童Leptin均值存在差异,肥胖/超重组汉族汉族Leptin均值高于哈萨克族（P=0.000）和回族（P=0.01）,差异均有统计学意义,回族和哈萨克族Leptin均值差异无统计学意义;非肥胖组汉族学龄儿童Leptin均值高于哈萨克族和回族,差异均有统计学意义（P=0.000）,回族Leptin均值高于哈族,差异有统计学意义（P=0.001）。（4）相关性分析和多元线性回归分析显示：Leptin与BMI、胰岛素呈正相关,Leptin水平与性别、民族、BMI、胰岛素水平呈正相关。结论肥胖儿童Leptin水平较正常儿童高,肥胖儿童存在Leptin抵抗;Leptin水平受性别、民族、体脂含量和胰岛素水平的影响。

Objective To understand the relationship between leptin and obesity of school-aged children in Urumqi of Xinjiang and if leptin level is influenced by ethnicity,gender and insulin levels.Methods Took the method of cluster sample in a few primary school in the areas around Urumqi,291 children aged 6 to 13 were taken and calculated BMI used the formula of weight（kg）/height2（m2）,and measured leptin and insulin concentrations by the way of RIA.Results（1） Leptin mean of obesity/overweight group was higher than that of non-obese group（P=0.000）;Insulin mean of obesity/overweight group was higher than that of non-obese group（P=0.009）.（2） Leptin mean of girls was higher than boys′ in Obesity/overweight group（P=0.048）;Leptin mean of girls was higher than boys′ in non-obese group（P=0.007）.（3） There were differences in leptin mean among the three ethnics,in obesity/overweight group,leptin mean of Han race was higher than that of Kazakh race（P=0.000） and Hui race（P=0.01）,the difference of Kazakh and Hui ethnic was not statistically significance;in non-obese group,leptin mean of Han race was higher than that of Kazakh race and Hui race（P=0.000）,the leptin mean of hui race is higher than that of Kazakh（P=0.01）.（4） Correlative analysis and multiple linear regression analysis showed that： BMI was positively correlated with leptin and insulin,Leptin levels was positively correlated with gender,ethnic,BMI and insulin level.Conclusion Leptin levels in obese children was higher than normal children,there had leptin resistance in obese children;Leptin level was influenced by gender,body fat content and insulin level.