VEGF-C及其受体Flt-4在肺鳞状细胞癌中的表达及其与淋巴结转移的关系

Expression and clinical significance of VEGF-C and Flt-4 in squamous cell of lung cancer and the relation with the lymphnode metastasis

目的探讨VEGF-C及其受体Flt-4在肺鳞状细胞癌中的表达及其与淋巴结转移的关系。方法采用免疫组化S-P法检测89例肺鳞状细胞癌原发灶组织、癌旁组织中VEGF-C、Flt-4的表达,并分析其与临床病理特征的关系。结果 (1)VEGF-C和Flt-4在癌组织中和转移的淋巴结转移组中高表达(P<0.05);(2)在肺鳞状细胞癌组织中VEGF-C、Flt-4的表达与分化程度相关(P<0.05),VEGF-C和Flt-4与吸烟指数相关(P<0.05),VEGF-C的表达与淋巴结转移呈正相关(P<0.05),与TNM分期相关(P<0.05);(3)VEGF-C与Flt-4在肺鳞状细胞癌细胞中的表达呈正相关(r=0.372,P<0.05)。结论 VEGF-C与Flt-4受体在肺鳞状细胞癌中高表达与淋巴结转移呈正相关。

Objective To study the protein expression and clinical significance of VEGF-C and Flt-4 in squamous cell of lung cancer and the relation with the lymph node metastasis.MethodsVEGF-C and Flt-4 expression were evaluated in the primary and adjacent normal tissues of 89 patients with squamous cell of lung cancer as well as lymphnode metastasis tissues of 41 patients by immunohistoehemistry（S-P method）.And analyse th relation to the clinic pathology.ResultsPositive expression rate of VEGF-C and Flt-4 in squamous cell of lung cancer and lymphnode metastasis tissues were higher than of normal tissues（P0.05）.There was correlation between the expression of VEGF-C and Flt-4 protein and histopathologic classification,smoking exponent（P0.05）.There was correlation between the expression of VEGF-C and TNM（P0.05）.The rate of lymphnode metastasis in high-expression group of 41 patients was higher than those in low-expression group（P0.05）.There was positive correlation between the expression of VEGF-C and Flt-4 in squamous cell of lung cancer（r=0.372,P0.05）.ConclusionThere was significantly correlation between the expression of VEGF-C and Flt-4 in squamous cell of lung cancer and lymphnode metastasis.