肺硬化性血管瘤临床病理特点及免疫表型分析

Clinical pathological characteristics and immunity phenotype analysis of sclerosing hemangioma of the lung

目的探讨肺硬化性血管瘤(SHL)的临床病理、组织来源及免疫组化特征。方法对5例SHL患者的临床和病理资料进行分析,用TTF-1、CK7、EMA、AEl/AE3、CK5/6、Vimentin、CD31、CD34、S-100、CgA、Syn、NSE、Calretinin、ER、PR、Ki-67共16种抗体进行免疫组化标记。结果肿瘤组织主要由乳头状区、实性区、血管瘤样区和硬化区4种组织形态以不同比例混合构成,瘤细胞主要由立方细胞和多角形/圆形细胞组成。2种细胞共同表达TTF-1和EMA,立方细胞表达AEl/AE3和CK7,多角形/圆形细胞表达Vimentin。结论 SHL的组织形态多样,SHL可能起源于多潜能的原始呼吸道上皮细胞,结合多种免疫组化的标记有助于该病的诊断。

Objective To investigate the clinic pathological characteristics and histogenesis of sclerosing hemangioma of the lung（SHL）.MethodsThe clinicopathological features of 5 sclerosing hemangiomas were analyzed.Using immunohistochemical methods,the expression of TTF-1,CK7,EMA,AEl/AE3,CK5/6,Vimentin,CD31,CD34,S-100,CgA,Syn,NSE,Calretinin,ER,PR and Ki-67 were observed in 5 cases of SHL.ResultsSHL exhibited the following histological features： papillary,sclerotic,solid,hemorrhagic,and mixed.The majority of tumors showed a mixed pattern of histology.The tumor is composed of two distinct cellular components,the round or polygonal or stroma cells and the cuboidal or surface cells.Immunohistochemical staining revealed the both kinds of cells expressed TTF-1 and EMA,the cuboidal cells expressed AEl/AE3 and CK7,the round or polygonal cells expressed vimentin.ConclusionSclerosing hemangioma exhibits various histologic findings,which probably originated from the epithelial cell of primary respiratory tract.Immunohistochemistry is helpful to dignosis.