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Atoh1基因在肺癌中的表达及临床意义 被引量：3

Expression and clinical significance of Atoh1 in lung cancer
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摘要 目的研究Atoh1(Atonalhomolog1)基因在肺癌中的表达。方法用实时荧光定量RT-PCR技术检测肺癌组织与癌旁组织中Atoh1的表达,采用表达的相对量进行结果分析。结果与癌旁组织相比,Atoh1 mRNA在肺癌组织中表达显著下调(P<0.05),两者比值约为0.46/1。结论 Atoh1基因在肺癌组织中的表达下调,可能与肺癌的发生、发展有关,可能成为诊断和治疗的新靶点。 Objective To investigate the Atoh1 expression in lung cancer.Methods Atoh1 mRNA expression levels in lung cancer tissues were tested by reverse transcription polymerase chain reaction（RT-PCR）.2-△△CT） method was used for analyzing the difference on Atoh1 expression.Result The levels of Atoh1 mRNA were down-regulated in lung cancer.Conclusion The down-regulation of Atoh1 expression may correlate with lung cancer.Atoh1 gene may serve as a new target for lung cancer diagnosis and treatment.
作者 陈嘉宝 刘俊华 刘益飞 薛小飞
机构地区 南通大学附属医院心胸外科 南通大学附属医院病理科
出处 《临床肺科杂志》 2011年第11期1744-1746,共3页 Journal of Clinical Pulmonary Medicine
关键词 Atoh1基因 肺癌 基因表达 Atoh1 gene Lung cancer Gene expression
分类号 R734.2 [医药卫生—肿瘤]
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参考文献7

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共引文献4

同被引文献46

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引证文献3

二级引证文献10

临床肺科杂志
2011年 第11期

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