高血压患者血清胱抑素-C和尿微量白蛋白检测的临床意义

Clinical significance of serum cystain-c levels and microalbuminuria in patients with hypertension

目的探讨尿微量白蛋白、血清胱抑素-C水平对高血压早期肾功能损害的临床诊断价值。方法免疫透射比浊法检测63例Ⅰ、Ⅱ、Ⅲ期高血压患者及52名健康体检者尿微量白蛋白及血清胱抑素-C。结果有蛋白尿组与无蛋白尿组高血压患者尿微量白蛋白、血清胱抑素-C水平均高于正常对照组(P<0.01),Ⅰ、Ⅱ、Ⅲ期高血压患者尿微量白蛋白和血清胱抑素-C检测结果高于正常对照组(P<0.01)。结论尿微量白蛋白和血清胱抑素-C水平是肾功能损害的早期标志物,联合检测可提高高血压患者早期肾功能损害检出率。

Objective To investigate the clinical value of UmAlb and SCys-C levels in the patients with early renal function injury caused by hypertension.Methods The concentration of U-mALb,SCYs-C in 63 cases of patients with Ⅰ,Ⅱ and Ⅲ of primary hypertension and 52 cases of healthy controls were determined with immune transmission nephelometry.Results U-mAlb and SCys-C levels in hypertension with proteinuria and not were higher than of that of normal control（P0.01）.U-mAlb and SCys-C levels in hypertension of Ⅰ,Ⅱ and Ⅲ were higher than of that of normal control（P0.01）.Conclusion U-mAlb and SCys-C are sensitive indexes of early renal function injury.The combined determination of U-mAlb and SCys-C is useful for early diagnosis and intervention for hypertension.