血清视黄醇结合蛋白4对非酒精性脂肪性肝炎的诊断价值

Significance of serum retinol-binding protein 4 in the diagnosis of patients with nonalcoholic steatohepatitis

目的探讨血清视黄醇结合蛋白4(RBP4)对非酒精性脂肪性肝炎(NASH)的临床诊断价值。方法选择经肝活检证实的NASH(42例)、单纯性脂肪肝(28例)和健康体检者(20例),采用ELISA法检测血清RBP4水平。以肝组织病理学检查结果为金标准,应用受试者工作特征曲线(ROC)评价血清RBP4对NASH的诊断价值。结果 NASH患者血清RBP4水平为37.11±7.68mg/L,明显高于单纯性脂肪肝患者(22.83±6.33mg/L,P<0.01)和对照人群(19.38±5.46mg/L,P<0.01);RBP4诊断NASH的AUC为0.804,灵敏度和特异度分别为79.6%和76.6%。结论NASH患者血清RBP4水平明显升高,可作为诊断NASH的敏感指标之一。

Objective To evaluate the clinical significance of serum retinol-binding protein 4（RBP4）in the diagnosis of patients with nonalcoholic steatohepatitis（NASH）.Methods Serum RBP4 was measured in triplicates by a specific enzyme-linked immunosorbent assay in 42 biopsy-proven patients with NASH,28 with fatty liver and 20 healthy people.The diagnostic performance of the serum RBP4 was assessed by analysis of receiver operating characteristic（ROC）curve.Results Serum RBP4 level in the NASH was 37.11±7.68mg/L,significantly higher than that in the simple steatosis cases（22.83±6.33mg/L,P0.01）or in control subjects（19.38±5.46mg/L,P0.01）;The area under the curve for serum RBP4 were 0.804 and the sensitivity and specificity for diagnosis of NASH were 79.6%和76.6%,respectively.Conclusion This study demonstrates that serum RBP4 levels may be a sensitive marker to detect patients with NASH.