摘要
肠道持续性慢性炎症是炎症性肠病(IBD)难以治愈的关键所在。造成肠道慢性炎症的核心机制是肠道血循环中淋巴细胞和血管内皮细胞的黏附和渗出。本文就主要黏附分子靶向抗黏附治疗的应用和临床地位作一简介。
Chronic persistent intestinal inflammation is the crucial factor of refractoriness of inflammatorty bowel disease(IBD).The core mechanism of chronic intestinal inflammation is the adhesion and exudation of intestinal circulatory lymphocytes and endotheliual cells.The aim of this article was to review the clinical significance and use of the major anti-adhesion therapy targeting against adhesive molecules in the treatment of chronic intestinal inflammation in IBD.
出处
《胃肠病学》
2011年第8期506-508,共3页
Chinese Journal of Gastroenterology
关键词
炎症性肠病
治疗
整合素类
血管细胞黏附分子-1
Inflammatory Bowel Disease
Therapy
Integrins
Vascular Cell Adhesion Molecule-1